CH1OR4-Further Fundamental Organic Chemistry for Biologists

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:4
Terms in which taught: Spring / Summer term module
Pre-requisites:
Non-modular pre-requisites: A level chemistry or equivalent
Co-requisites: CH1OR2 Fundamentals of Organic Chemistry
Modules excluded: CH1FC1 Fundamental Concepts in Chemistry 1 or CH1FC3 Molecular Studies for the Life Sciences or CH1OR1 Shape, Structure and Reactivity in Organic Chemistry
Module version for: 2017/8

Module Convenor: Dr Andrew Russell

Email: a.t.russell@reading.ac.uk

Summary module description:

Aims:
To further students’ understanding of basic concepts in organic chemistry in order to better appreciate related subjects such as Biochemistry, Biomedical Sciences and Medicinal Chemistry.

Assessable learning outcomes:
Students should be able to describe and explain the reactivity of alkenes and alkynes toward a selection of reagents, describe and explain the concept of aromaticity; explain the mechanisms of EAS and NAS reactions; explain the mechanisms of nucleophilic attack upon a variety of carbonyl containing groups; use their knowledge of this fundamental reactivity of organic functional groups to rationalise simple synthetic transformations and to interpret some fundamental reactions observed in biological systems.

Additional outcomes:
Students will develop proficiency at problem solving.

Outline content:

L M Harwood (4 lectures) Reactivity of Unsaturated Compounds We will study reactions that are characteristic of the alkene/alkyne functional groups. For example, reactions of alkenes with a range of electrophiles, including Br2, HBr, BH3 and m-CPBA will be described. The regioselective addition of electrophiles to unsymmetrical alkenes will also be discussed and Markovnikov’s rule will be exemplified. P B Cranwell (8 lectures) Aromatic Chemistry We will study the structure of benzene, the Hückel rule for aromaticity and the stability of aromatic molecules. The reactivity of these compounds will be considered under the general mechanistic headings; electrophilic aromatic substitution (EAS) and nucleophilic aromatic substitution (NAS) as well as the structure and reactivity of benzyne. The significance of substituents on the regiochemistry of these reactions will be discussed. Additionally, the synthesis and reactions of diazoaromatics will be covered. A T Russell (8 lectures) An Introduction to Carbonyl Group Chemistry We will consider the structure and bonding of the carbonyl functional group, its fundamental modes of reactivity including the link between structure and reactivity. The reactions of carbonyl groups with nucleophiles and reducing agents will be covered together with methods of formation, methods of removal and the chemistry of carboxylic acids, esters and amides.


Brief description of teaching and learning methods:
Two one hour lectures per week with approximately one workshop/seminar on related material every three weeks with 2 hours of revision classes in the Summer Term.

Contact hours:
  Autumn Spring Summer
Lectures 20
Seminars 6 2
Practicals classes and workshops 12
Guided independent study 42 18
       
Total hours by term 80.00 20.00
       
Total hours for module 100.00

Summative Assessment Methods:
Method Percentage
Written exam 75
Report 25

Other information on summative assessment:

Coursework: Students will attend practical sessions on standard laboratory techniques in organic chemistry. Relative Percentage of Coursework: Practical work and practical report: 25% of the Module mark. Submission dates: practical reports would normally be submitted the Friday following each Monday practical, detailed instructions will be given by the class leader.


Formative assessment methods:
Students will attend problem-solving workshop/seminars on the material covered in this module. This will give students a chance to work on set questions with members of staff present to give feedback and guidance. Attendance is compulsory.

Penalties for late submission:
The Module Convenor will apply the following penalties for work submitted late, in accordance with the University policy.

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at: http://www.reading.ac.uk/web/FILES/qualitysupport/penaltiesforlatesubmission.pdf
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Length of examination:
    1.5 hours

    Requirements for a pass:
    A mark of 40% overall.

    Reassessment arrangements:
    Reassessment will comprise of an examination worth 75% and a practical assessment worth 25%.

    Additional Costs (specified where applicable):

    Last updated: 8 May 2017

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