PM3A-Therapeutics and Medicines Optimisation D

Module Provider: Pharmacy
Number of credits: 40 [20 ECTS credits]
Level:6
Terms in which taught: Autumn / Spring / Summer module
Pre-requisites: PM2A2 Therapeutics and medicines optimisation A2: Molecules and Medicines or PM2A2M Therapeutics and Medicines Optimisation A: Molecules and Medicines (UoRM Campus) and PM2B Therapeutics and Medicines Optimisation B: A Journey Through the GI Tract or PM2BM Therapeutics and Medicines Optimisation B: A Journey Through the GI Tract (UoRM Campus) and PM2C2 Therapeutics and medicines optimisation C2: Therapeutics and Patient care or PM2C2M Therapeutics and Medicines Optimisation C2: Therapeutics and
Non-modular pre-requisites:
Co-requisites: PM3B Therapeutics and Medicines Optimisation E and PM3C Delivering Pharmacy Services 2
Modules excluded:
Current from: 2017/8

Module Convenor: Dr Hisham Al-Obaidi

Email: h.al-obaidi@reading.ac.uk

Type of module:

Summary module description:

This module brings into context material taught in Part 2 modules involving analytical and formulation science and therapeutics. It initially focuses teaching around the therapeutic area of immunology and infections (building on microbiology and infections material taught in Part 1 and 2), allergy, immunodeficiency and autoimmune disease. The module then introduces medical conditions related to reproductive health (which is linked to endocrinology teaching in PM3B), the skin/dermatology, eye, ear, nose and throat. Each topic includes aspects of physiology, pathology, disease management and prevention, medicine design and patient management. In addition, tissue engineering for skin and eye conditions is introduced. Medicines design is considered for local administration and systemic delivery via the administration routes relevant to the systems covered here (e.g. topical administration through the skin, eyes and ears and vaginal administration of medicines), using appropriate examples that link to PM3B and PM3C. Basic First Aid including CPR and use of defibrillators is also covered in addition to vaccination workshops.  


Aims:

This module aims to build upon the core science and practice concepts taught in parts 1 and 2, encouraging students to apply them to a range of new medical conditions and pharmaceutical challenges. It also introduces more advanced concepts in pharmacy-related sciences and patient management with emphasis on conditions that pharmacists deal with on regular basis such as inflammatory responses, eye condtions and vaccinations and infections. 


Assessable learning outcomes:
Core module “systems”:
Immunology & Infections; Dermatology; Eye, Ear and Nose; Reproductive system & Men’s and Women’s Health

Students will be able to:
• Discuss the anatomy and physiology of the core “systems” listed above
• Discuss the aetiology, pathology, diagnosis and prevention of medical conditions affecting these “systems”
• Discuss the non-drug management of these medical conditions, including complementary medicine where appropriate
• Discuss the pharmaceutical management of these medical conditions, including:
o Drug treatment options and their place in therapy (including natural products where relevant)
o The evidence available and its utilisation to support recommendations for disease management
o Drug chemistry, discovery, design and delivery of drug treatment options (including formulations, biopharmaceutics and devices for injectable, ocular, otic, nasal, vaginal, topical and transdermal delivery)
o Pharmacology (including pharmacokinetics and pharmacodynamics) of drugs used in treatment
o Monitoring for safety and efficacy of treatment and action that should be taken in view of results obtained
o Patient centred care and medicines optimisation: tailoring treatment to the individual, personalised medicine, effect of disease on the patient, health beliefs & behaviours, promoting adherence and self-care, providing medicines-related information with a knowledge of health policies
o The role of the pharmacist, including how they may work with public groups to improve outcomes
o How pharmacists may work with other healthcare professionals to achieve effective patient care
o Public health aspects, where appropriate
• Identify and accurately record patient data relevant to pharmaceutical care
• Discuss and demonstrate how the science of pharmacy is applied in the design and development of medicines and devices towards the packaging and storage of, and safe and rational use of medicines
• Prepare patient information leaflets for the instruction of safe and effective use of medicines
• Promote public health through the preparation and presentation of public health promotion materials
• Communicate effectively and support colleagues within a team and demonstrate leadership skills while working in a team and present information to a wider audience

Additional outcomes:
In addition to the assessed outcomes, this module develops students’ skills towards additional learning outcomes that are summatively assessed in other Part 3 modules or later in the programme. These are skills relating to health and safety, quality management of medicines and maintaining records and communicating with patients (e.g. patient counselling, responding to symptoms).

Outline content:

Introduction to module • Puts the module in context with Part 3 teaching and explains the key concepts covered within the module Immunology • Introduction to the immune system • Atopy / hypersensitivity: food allergies, hay fever, adverse drug reactions • Autoimmune diseases: ulcerative colitis, Crohn’s disease, coeliac disease, type 1 diabetes mellitus, Grave’s disease, rheumatoid arthritis, polymyalgia rheumatica, psoriasis • Immunodeficiency and immunocompromisation: HIV/AIDs • Immunosuppressants Infection • Bacterial, viral, fungal and parasitic conditions • Vaccination • Infection control • Antimicrobial therapy (including advanced synthesis and manufacture of penicillins); antimicrobial resistance & antimicrobial stewardship • Infections in core systems (across PM3A and PM3B as well as core systems introduced in Part 2) Dermatology • The dermatological / integumentary system • Diseases affecting the skin: tinea infections (nappy rash, athlete’s foot, ringworm, “jock itch”), cellulitis, cold sores, warts, calluses, dermatitis, eczema, psoriasis, acne vulgaris, rosacea, scabies, lice, boils, alopecia, hyper/hypo-pigmentation, burns, impetigo, nail infections (onychomycosis), sunburn, skin cancer • Adverse drug reactions affecting the skin • Responding to symptoms – minor ailments affecting the skin • Wounds and wound healing, dressings • Formulation of medicines for topical dermal and transdermal delivery (also linked to men’s and women’s health – e.g. testosterone gel, HRT patch) • Tissue engineering – skin substitutes, cellular and non-cellular therapy Eye, Ear, Nose and Throat Diseases of the ear, eye, nose and throat typically encountered by pharmacists: • Ear (e.g. otitis media, otitis externa, ear wax), drugs causing ototoxicity • Eye disorders (e.g. blepharitis, conjunctivitis, glaucoma, dry eyes), side effects of drugs on the eye – blurred vision, change in pigmentation etc. issues with contact lenses. • Nose: congestion - hay fever & cough/cold, polyps • Throat: pharyngitis, tonsillitis • Responding to symptoms – minor ailments affecting the eyes & ears • Formulation of medicines for ocular, otic and nasal delivery • Tissue engineering – ocular surface stem cell therapy Reproductive, Men’s and Women’s Health • Development of the reproductive system, puberty and the menstrual cycle • Fertility and pregnancy. Contraception and contraceptive devices • Women’s health: menstrual cycle disorders including dysmenorrhoea, menorrhagia, menopause, endometriosis, infertility, vaginal atrophy, contraceptives, vaginal thrush, cystitis, bacterial vaginosis, pelvic inflammatory disease, breast cancer • Formulation of medicines for vaginal delivery • Men’s health: impotence/erectile dysfunction (including as side effects of drugs), infertility, benign prostatic hyperplasia, testicular cancer, male-pattern baldness. • Sexual health: sexually transmitted infections – chlamydia, syphilis, genital herpes, gonorrhoea, human papillomavirus, trichomoniasis, link to HIV/AIDS • Genitourinary health: urinary tract infection, incontinence, urinary retention Practical classes: Practical classes form part of the Part 3 integrated practical series that link across all three Part 3 modules.


Brief description of teaching and learning methods:

Teaching and learning methods are through lectures, workshops, practical classes, problem-based learning and directed private study. There are two additional workshop-style sessions linked to supporting students with their personal and academic development (PAD) portfolio and independent study time allocated to this activity. Three two-hour tutorial/feedback sessions are also timetabled to support students in their preparation for assessments. Student learning in this module will be supported by a symposium to be held in spring term around the core systems covered throughout Parts 2 and 3.


Contact hours:
  Autumn Spring Summer
Lectures 36 30
Seminars 4
Tutorials 2 2 2
Practicals classes and workshops 28 31
Guided independent study 109 119 37
       
Total hours by term 179.00 182.00 39.00
       
Total hours for module 400.00

Summative Assessment Methods:
Method Percentage
Written exam 30
Written assignment including essay 10
Project output other than dissertation 10
Class test administered by School 50

Summative assessment- Examinations:
There will be a three-hour synoptic examination, which will assess content of PM3A and PM3C and include, where relevant, concepts covered in PM3B and previous years.

Summative assessment- Coursework and in-class tests:

Students will be provide with tutorials and on-line assessments to help them prepare for the final examination. The January assessment (in-course examination) will predominantly assess material taught in PM3A in the Autumn term, whilst the April/May assessment (in-course examination) will cover material taught in PM3A in the Spring term. These in-course assessments will also assess relevant content taught in PM3C. Both in-course examinations will be in the form of MCQs and each will be worth 25% of the module marks (50% in total). The final synoptic examination will assess content of PM3A and PM3C and will include, where relevant, concepts covered in PM3B and previous years of the programme. This will be worth 30% of the module marks. The written assignment is linked with the infections PBL, which is a group activity with individual and group summative assessment elements collectively worth 10% of the module marks. There will also be a Medicines Design 2 project that will be worth 10% of the module marks.


Formative assessment methods:

Each term will have a minimum of one formatively assessed activity. In Autumn term there is an Immune System-based workshop on anaphylaxis in addition to vaccination techniques workshop. In Spring term this will be assessment on presentations that form part of the Core Systems Symposium.


Penalties for late submission:
The Module Convener will apply the following penalties for work submitted late:

  • where the piece of work is submitted after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for that piece of work will be deducted from the mark for each working day[1] (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at: http://www.reading.ac.uk/web/FILES/qualitysupport/penaltiesforlatesubmission.pdf
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Assessment requirements for a pass:
    The student shall normally be required to achieve an overall weighted average of at least 40% for the module .

    Reassessment arrangements:
    Re-examination of written examinations will be in August and will be by written examination.

    Additional Costs (specified where applicable):
    1) Required text books: The University library has a large number of text books and specialised reading material. There are also an excellent number of e-books available to the students. There might be core text books, which the students wish to purchase at varying costs.
    2) Specialist equipment or materials: None
    3) Specialist clothing, footwear or headgear: None but students must be appropriately dressed for laboratory-based practical sessions.
    4) Printing and binding: There are no specific printing costs as work is submitted electronically through Blackboard. Should students may wish to print teaching materials and currently library costs for printing are 5p a sheet (black &white).
    5) Computers and devices with a particular specification: None
    6) Travel, accommodation and subsistence: None

    Last updated: 11 May 2018

    THE INFORMATION CONTAINED IN THIS MODULE DESCRIPTION DOES NOT FORM ANY PART OF A STUDENT'S CONTRACT.

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