FB3NGL-Genes, Lifestyle and Nutrition (Part taught with FBMNH2)

Module Provider: Food and Nutritional Sciences
Number of credits: 20 [10 ECTS credits]
Terms in which taught: Autumn / Spring term module
Non-modular pre-requisites: Pre-requisites: FB3NGL and FB3NGLA are mutually exclusive modules
Modules excluded:
Module version for: 2017/8

Module Convenor: Dr Vimal Karani

Email: v.karani@reading.ac.uk

Summary module description:

To provide students with an understanding of clinical, biochemical and molecular genetic basis of complex diseases such as metabolic (obesity and diabetes) and cardiovascular disease- related traits and to provide them with an understanding of topical issues in nutritional sciences which have made major advancements over the decade including the areas of genetic and nutritional epidemiology, gene-diet and gene-physical activity interactions, epigenetics, foetal origin of adult disease and personalised nutrition.

Assessable learning outcomes:
On completion of the module, the student should

- Understand the basics of molecular genetics and genetic epidemiology of multifactorial diseases.
- Understand the flow of biological information and macromolecular interactions in the context of gene expression.
- Have developed an insight into the contribution of genetic variation to disease risk.
- Understand the methods employed to identify human genes involved in metabolic and cardiovascular disease outcomes.
- Have developed an in-depth understanding of the biochemical and clinical aspects of human genetic diseases.
- Have developed an understanding of the impact of lifestyle factors, in particular diet, on the association between genotype and disease.
- Understand the concepts of the contribution of foetal nutrition to later disease development.
- Have developed an understanding of the concept of personalised nutrition

Additional outcomes:
Development of a number of key skills such as critical evaluation, use of on-line databases, presentation and writing skills

Outline content:
During the Autumn Term the module deals with providing lectures on the basics of molecular genetics and genetic epidemiology. Specific topics include: DNA Replication, RNA Transcription, Translation, Principles of genetic epidemiology, gene discovery methods in genetic epidemiology, Clinical genetics, Population genetics and Biochemical genetics.

During the Spring Term, a range of additional topics are covered including: Introduction to gene structure and regulation and chronic diseases, epigenetics, gene-lifestyle interactions – diet and physical activity, diet-genotype interactions- complex traits such as diabetes, obesity and CVDs, Diet genotype interactions- cancer, foetal origin of adult disease and personalised Nutrition.

Brief description of teaching and learning methods:
During the Autumn Term, the module consists primarily of lectures. The coursework comprises one short-answer test of 90 minutes (autumn term) and Non-lab based practical class test on Statistical Genetics (spring term). During the Spring Term the module will be primarily taught as informal small group interactive lectures given by academics who have active research groups in the area. In addition, there will be a debate session on personalised nutrition in the spring term. There will be a non-lab based practical session where students will get the opportunity to learn the statistical methodologies involved in testing gene-diet interactions using the available statistical software's.

Contact hours:
  Autumn Spring Summer
Lectures 20 14
Practicals classes and workshops 9
Guided independent study 80 77
Total hours by term 100.00 100.00
Total hours for module 200.00

Summative Assessment Methods:
Method Percentage
Written exam 80
Practical skills assessment 10
Class test administered by School 10

Other information on summative assessment:

• Autumn term: Class Test - Short answer module written test. Submission Deadline: End of Autumn Term • Spring term: Non-lab based practical class test on Statistical Genetics. Submission Deadline: End of Spring Term

Formative assessment methods:
•Debate on ‘Personalised Nutrition’ in the spring term

Penalties for late submission:
The Module Convenor will apply the following penalties for work submitted late, in accordance with the University policy.

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at: http://www.reading.ac.uk/web/FILES/qualitysupport/penaltiesforlatesubmission.pdf
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Length of examination:
    2 hours

    Requirements for a pass:
    Pass mark for the module is 40%

    Reassessment arrangements:
    Written examination during the University re-examination period in August.

    Additional Costs (specified where applicable):
    1) Required text books:
    2) Specialist equipment or materials:
    3) Specialist clothing, footwear or headgear:
    4) Printing and binding:
    5) Computers and devices with a particular specification:
    6) Travel, accommodation and subsistence:

    Last updated: 31 March 2017

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