CH4O4-Oligosaccharides and Natural Products

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Terms in which taught: Spring term module
Pre-requisites: CH3O1 Advanced Organic Chemistry - Synthesis of Complex Targets
Non-modular pre-requisites:
Modules excluded:
Module version for: 2016/7

Module Convenor: Dr Geoffrey Brown


Summary module description:
This module aims to provide the student with an overview of advanced organic chemistry.

To enable the student to gain an understanding of the breadth of modern chemistry and demonstrate that organic chemistry is a multi-disciplinary science. Additionally, students will take part in a group-based problem solving exercise that will help them to understand how a medicinal chemist applies synthetic organic chemistry to the development of a drug.

Assessable learning outcomes:
Students who have successfully completed this module will be able to:
• Understand the biological role played by complex carbohydrates and describe current synthetic methodology for the construction of such molecules.
• Outline the different classes of secondary metabolites and describe their biosynthesis.
• Carry out an analysis of the synthesis of a potential drug and design routes to prepare analogue structures.
• Demonstrate an ability to plan a synthesis to deliver a range of compounds for a drug discovery programme.

Additional outcomes:

Outline content:
J. E. McKendrick/A. T. Russell (10 workshops) - Synthesis in Medicinal Chemistry
This course will see the class split into teams and each team assigned a synthetic, medicinal chemistry task. The team will be charged with completing the task set through appropriate division of labour. The problem will rely heavily on synthetic chemistry and the students’ ability to research the literature, taking advantage of databases such as Reaxys and SciFinder. The exercise will be assessed via an oral and written component. Feedback and guidance is available throughout during the timetabled workshops.

H. M. I. Osborn (6 lectures) - Oligosaccharides
Different strategies for the synthesis of oligosacharrides of biological significance will be discussed, including enzymatic and solid phase syntheses.

G.D. Brown (8 lectures) - Natural Products and their Biosynthesis
Most classes of secondary metabolites will be covered, including terpenoids and steroids (derived from both the mevalonate and DXP pathways), alkaloids (derived from amino acids) and acetogenins. In addition to their biosynthesis, the medicinal and/or toxicological importance of natural products will be stressed, as well as their ecological significance.

Brief description of teaching and learning methods:
10 x 1 hour workshop seminars. 14 x 1 hour lectures with 2 associated tutorials.
Summer hours are scheduled for revision.

Contact hours:
  Autumn Spring Summer
Lectures 14
Tutorials 2
Supervised time in studio/workshop 11
Guided independent study 53 20
Total hours by term 80.00 20.00
Total hours for module 100.00

Summative Assessment Methods:
Method Percentage
Written exam 50
Written assignment including essay 30
Oral assessment and presentation 20

Other information on summative assessment:
Students will attend seminars to assist with a team chemical synthesis problem. Each student will be assessed by an individual written piece of work and by giving a team oral presentation on their work and. In each case we will examine how the team worked together to achieve the common goal as well as the individual’s work.
Relative percentage of coursework: Synthesis exercise 50%.

Submission dates: written report on problem solving exercise to be handed in on the last Friday of Spring term.

Formative assessment methods:
Feedback in seminars to assist with a team chemical synthesis problem.
Students will attend tutorials on the lecture material covered in this module. Attendance is compulsory. A tutorial comprises both written work and oral contribution. Tutorials to be submitted as detailed on Blackboard.

Penalties for late submission:
The Module Convenor will apply the following penalties for work submitted late, in accordance with the University policy.

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at:
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Length of examination:
    1 hour.

    Requirements for a pass:
    An overall mark of 50%.

    Reassessment arrangements:
    Reassessment will be held in August and will comprise of an examination worth 50%, a written report worth 30% and an oral presentation worth 20%.

    Final year students are not eligible to resit this module unless they have failed their degree programme overall.

    Additional Costs (specified where applicable):
    1) Required text books:
    2) Specialist equipment or materials:
    3) Specialist clothing, footwear or headgear:
    4) Printing and binding:
    5) Computers and devices with a particular specification:
    6) Travel, accommodation and subsistence:

    Last updated: 21 December 2016

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