CH4O1-Advanced Organic Chemistry - Synthesis of Complex Targets (2)

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Terms in which taught: Autumn term module
Pre-requisites: CH3O1 Advanced Organic Chemistry - Synthesis of Complex Targets
Non-modular pre-requisites:
Modules excluded:
Module version for: 2016/7

Module Convenor: Dr Geoffrey Brown


Summary module description:
This module aims to provide the student with an overview of modern synthetic organic chemistry.

The course will provide the student with the tools required to approach the synthesis of complex molecular targets, in particular the student will be introduced to enantioselective synthesis, multi-step synthesis and the chemistry of heterocycles which incorporate more than one heteroatom.

Assessable learning outcomes:
Students who have successfully completed this module will be able to:

• Describe the processes through which one enantiomer of a given molecular target may be synthesised.
• Be able to explain and apply selected methods of asymmetric synthesis to unseen synthetic problems.
• Describe the synthesis and properties of heterocyclic compounds and apply the knowledge to aid an understanding of their role in biological systems.

Additional outcomes:

Outline content:
Andy Russell & Chris Smith (8 lectures) The Elements of Asymmetric Synthesis
This course will examine the general principles underlying asymmetric synthesis. In particular we will examine the need to generate diastereoisomeric transition states in order to achieve asymmetric induction. We will examine the relative merits of chiral auxiliaries and chiral catalysts then exemplify these with reactions of great synthetic significance, e.g. the Evans enolate alkylation and the Sharpless epoxidation.

Andy Russell & Chris Smith (6 lectures) Contemporary Organic Synthesis
We will discuss the applications of the methods learnt in ‘The Elements of Asymmetric Synthesis’ course in a synthetic context and supplement this with a discussion of other carbon-carbon bond forming reactions such as the Claisen rearrangement.

Geoff Brown (8 lectures) Advanced Heterocyclic Chemistry
Chemistry and synthesis of complex heteroaromatics, pyridazines, pyrazines, pyrimidines. Complex heteroaromatics in nature.

Brief description of teaching and learning methods:
Two one hour lectures per week with approximately one tutorial or workshop on related material every three weeks.

Contact hours:
  Autumn Spring Summer
Lectures 22
Tutorials 3
Guided independent study 75
Total hours by term 100.00
Total hours for module 100.00

Summative Assessment Methods:
Method Percentage
Written exam 100

Other information on summative assessment:

Formative assessment methods:
Students will attend tutorials on the material covered in this module. Attendance is compulsory. A tutorial comprises both written work and oral contribution.

Tutorials to be submitted as detailed on Blackboard.

Penalties for late submission:

For students on chemistry-based degree courses any unexplained absence from more than two tutorials in chemistry in any term will automatically incur a formal warning from the School Director of Teaching and Learning.
The Module Convenor will apply the following penalties for work submitted late, in accordance with the University policy.
  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at:
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Length of examination:
    1.5 hours

    Requirements for a pass:
    An overall mark of 50%.

    Reassessment arrangements:
    Reassessment will be held in August and will be by examination only worth 100%.
    Final year students are not eligible to resit this module unless they have failed their degree programme overall.

    Additional Costs (specified where applicable):
    1) Required text books:
    2) Specialist equipment or materials:
    3) Specialist clothing, footwear or headgear:
    4) Printing and binding:
    5) Computers and devices with a particular specification:
    6) Travel, accommodation and subsistence:

    Last updated: 21 December 2016

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