CH4MM2-Medicinal Chemistry 2

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:7
Terms in which taught: Spring and Summer
Pre-requisites: CH2MMC Medicinal Chemistry for Chemists CH3O2 Advanced Organic Chemistry - Contemporary Synthetic Methodology CH3O1 Advanced Organic Chemistry - Synthesis of Complex Targets
Non-modular pre-requisites:
Co-requisites: CH4O1 Advanced Organic Chemistry - Synthesis of Complex Targets (2)
Modules excluded:
Module version for: 2012/3

Module Convenor: Prof Laurence Harwood

Email: l.m.harwood@reading.ac.uk

Aims:
Students will learn the neuronal structure of the CNS, the role of neurotransmitters and by applying this knowledge understand the development of chemotherapeutic strategies to treat neurological conditions. The students will gain an appreciation of the interdisciplinary nature of the subject as they draw on the relevant aspects of pharmacology and biochemistry to enhance their understanding of the chemistry. Additionally, the students will take part in a group-based problem solving exercise that will help them to understand how a Medicinal Chemist applies synthetic organic chemistry to the development of a drug.

Assessable learning outcomes:
• Carry out an analysis of the synthesis of a potential drug and design routes to prepare analogue structures.
• Discuss the neuronal structure of the CNS and receptor mediated signalling.
• Explain the molecular basis of diseases of the CNS and their treatment by pharmaceuticals.
• Demonstrate an ability to plan a synthesis to deliver a range of compounds for a drug discovery programme.

Additional outcomes:

Outline content:
L M Harwood (10 lectures) The Central Nervous System
We will discuss the neuronal structure of the CNS and the role of neurotransmitters. We will then study a range of drug types that act on the CNS such as analgesics, antipsychotics and anxiolytics. In addition, we will examine dementias such as Alzheimer’s and Parkinson’s disease and methods for treating them by drug based approaches.

J E McKendrick/A T Russell (10 workshops) Synthesis in Medicinal Chemistry
This course will see the class split into teams and each assigned the same synthetic, medicinal chemistry task. The team will be charged with completing the task set through appropriate division of labour. The problem will rely heavily on synthetic chemistry and the students’ ability to research the literature. The exercise will be assessed via an oral and written component. Feedback and guidance is available throughout during the timetabled workshops.

Brief description of teaching and learning methods:
10 one-hour lectures, 10 one-hour workshops.

Contact hours:
  Autumn Spring Summer
Lectures 10 1
Supervised time in studio/workshop 11
Guided independent study 58 20
       
Total hours by term 0 79 21
       
Total hours for module 100

Summative Assessment Methods:

Method Percentage
Written exam 50
Written assignment including essay 30
Oral assessment and presentation 20

Other information on summative assessment:
Students will attend workshops to assist with a team chemical synthesis problem. Each student will be assessed by giving an oral presentation on their work and by a written piece of work. In each case we will examine how the team worked together to achieve the common goal as well as the individual’s work.

Relative percentage of coursework: Synthesis excercise 50%

Submission dates: written report on problem solving exercise to be handed in on the last Friday of term.

Formative assessment methods:
Feedback in workshops to assist with a team chemical synthesis problem.

Penalties for late submission:
Penalties for late submission on this module are in accordance with the University policy.
The following penalties will be applied to coursework which is submitted after the deadline for submission:

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark;
  • where the piece of work is submitted more than one calendar week after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • You are strongly advised to ensure that coursework is submitted by the relevant deadine. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.
    (Please refer to the Undergraduate Guide to Assessment for further information: http://www.reading.ac.uk/internal/exams/student/exa-guideUG.aspx)

    Length of examination:
    1 hour

    Requirements for a pass:
    A mark of 40%

    Reassessment arrangements:
    Re-examination will take place in the August/September following final examinations, for the examinable component only, when a student has failed the programme overall.

    Last updated: 7 May 2012

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