CH4AN1-Advanced Analytical Techniques for the Molecular Sciences

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Terms in which taught: Autumn
Pre-requisites: CH2AN3 Analytical Chemistry or CH2AN1 Analytical Chemistry and Professional Skills 1
Non-modular pre-requisites: Part 2 Chemistry
Modules excluded:
Module version for: 2012/3

Module Convenor: Prof Rainer Cramer


Summary module description:
Study of some modern analytical chemistry techniques relevant to the molecular sciences

To give students familiarity in theory and applications of some advanced analytical techniques.

Assessable learning outcomes:
Students should develop an understanding for the analytical techniques covered in the module. They should appreciate how such techniques can be used independently and in conjunction with other techniques to elucidate molecular structure and identity. Students should be able to solve problems in analytical chemistry based upon application of the techniques.

Additional outcomes:
Students will gain experience in problems solving, numeracy and report writing.

Outline content:
G D Brown (8 lectures + 1 practical) Nuclear Magnetic Resonance Spectroscopy
Revision of basic principles, vector model and rotating frame analysis, pulsed-Fourier transform NMR, carbon NMR (coupling constants, broadband decoupling), 2D-NMR, including J-resolved spectra and homo- and heteronuclear correlation, protein NMR, 3D-NMR.
R K Cramer (3 lectures (3 x 2 hours) + 1 workshop/practical (2 hours)) Advanced Mass Spectrometry
Revision of basic principles and instrumentation, fragmentation in mass spectrometry and spectral interpretation, quantitative analysis, hyphenation of other analytical and preparative techniques with mass spectrometry (incl. interfacing chromatographic instrumentation with a mass spectrometer), introduction to modern biological/biochemical mass spectrometry.
R K Cramer (2 lectures (2 x 2 hours)) Electrophoretic Methods of Analysis
Electrophoresis and related topics. Survey of the range of electrophoretic techniques available for the separation, purification and analysis of polymers, macromolecules and biomolecules such as proteins and DNA with an introduction to biomacromolecules.
F Hartl (3 lectures (2 x 2 hours) + 1 workshop) Advanced Electrochemical Methods of Analysis
Chronoamperometry, chronocoulometry, rotating disk and ring-disk electrode, stripping voltammetry and differential pulse voltammetry (the latter two representing electroanalytical methods); mechanisms of redox reactions.

Brief description of teaching and learning methods:
22 hours lectures plus associated workshops and instrument visits

Contact hours:
  Autumn Spring Summer
Lectures 22
Supervised time in studio/workshop 4
Guided independent study 74
Total hours by term 100.00
Total hours for module 100.00

Summative Assessment Methods:

Method Percentage
Written exam 100

Other information on summative assessment:

Formative assessment methods:
Students will attend problem solving workshops on the topics covered in lectures.

Penalties for late submission:
Penalties for late submission on this module are in accordance with the University policy.
The following penalties will be applied to coursework which is submitted after the deadline for submission:

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark;
  • where the piece of work is submitted more than one calendar week after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.
    (Please refer to the Undergraduate Guide to Assessment for further information:

    Length of examination:
    1.5 hrs

    Requirements for a pass:
    A mark of 40 % overall.

    Reassessment arrangements:
    Re-examination will take place in August / September following final examinations, for the examinable component only, when a student has failed the programme overall.

    Last updated: 21 June 2012

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