CH3O1-Advanced Organic Chemistry - Synthesis of Complex Targets

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Terms in which taught: Autumn
Pre-requisites: CH2OR1 Further Organic Chemistry
Non-modular pre-requisites:
Modules excluded:
Module version for: 2012/3

Module Convenor: Prof Laurence Harwood


To extend the synthetic methods introduced in previous years to the preparation, characterisation and manipulation of macromolecules and materials of biological and synthetic origin.

Assessable learning outcomes:
Students who have successfully completed this module will be able to:
• Describe the various classes of chiral molecules that are available from natural sources.
• Outline the use of these chiral precursors in the synthesis of more complex natural products.
• Choose appropriate methods for the synthesis of specific polymers.
• Outline the relationship between structure and physical characteristics of macromolecular materials.

Additional outcomes:
Lectures will provide an overview of the synthesis and utility of natural and non-natural monomer units and their assembly into complex polymers. Students will gain experience of the chemistry used in the construction of such complex materials via small group tutorials.

Outline content:
G Brown (10 lectures) Introduction to the Chemistry of the Chiral Pool
A survey of basic amino acid synthesis; N- and C-terminal protection and activation; peptide coupling in solution and in the solid phase. Structures, typical reactions, protection and use of carbohydrates in synthesis.

F J Davis (10 lectures) Polymer Chemistry
Radical, cationic and anionic polymerisation processes and the structural classes of the polymers that may be formed. Molecular weight determination, polymer characterisation.

Brief description of teaching and learning methods:
Two one hour lectures per week with approximately one tutorial on related material every two weeks.

Contact hours:
  Autumn Spring Summer
Lectures 20
Tutorials 3
Guided independent study 77
Total hours by term 100 0 0
Total hours for module 100

Summative Assessment Methods:

Method Percentage
Written exam 80
Written assignment including essay 16
Oral assessment and presentation 4

Other information on summative assessment:
Students will attend 3 tutorials on the material covered in this module. Attendance is compulsory. A tutorial comprises both written work and oral contribution. A maximum of 20 marks is available for the written work and 5 marks for the oral contribution for each tutorial set.

Submission dates:
Tutorials to be submitted as detailed on Blackboard

Formative assessment methods:

Penalties for late submission:
For students on chemistry-based degree courses any unexplained absence from more than two tutorials in chemistry in any term will automatically incur a formal warning from the School Director of Teaching and Learning.

Length of examination:
1.5 hours

Requirements for a pass:
A mark of 40% overall.

Reassessment arrangements:
Re-examination will take place in the September following final examination when a student has failed the programme overall. The re-examination will be by exam only.

Last updated: 7 May 2012

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