CH2MC2-Medicinal Chemistry 2 for Chemists

Module Provider: Chemistry
Number of credits: 10 [5 ECTS credits]
Level:5
Terms in which taught: Autumn term module
Pre-requisites: CH1OR1 Shape, Structure and Reactivity in Organic Chemistry CH1PH1 Physical Processes and Molecular Organisation
Non-modular pre-requisites:
Co-requisites:
Modules excluded:
Module version for: 2016/7

Module Convenor: Dr John McKendrick

Email: j.e.mckendrick@reading.ac.uk

Summary module description:
To build on the basic concepts of Organic and Physical chemistry to develop an understanding of the basic principles of medicinal chemistry.

Aims:
To build on the basic concepts of Organic and Physical chemistry to develop an understanding of the basic principles of medicinal chemistry.

Assessable learning outcomes:
Students should be able to:
(i) State and discuss the main pathways of primary metabolism.
(ii) Discuss the absorption, distribution, metabolism and excretion of drugs.
(iii) Understand the role of amino acids and non-amino acids in biochemical transformations.
(iv) Explain the function of some classes of enzymes in terms of the chemical reactions that are catalysed.

Additional outcomes:

Outline content:
A T Russell (8 lectures) Introduction to Medicinal Chemistry
A study of the pathways for absorption, distribution, metabolism and excretion (ADME) of drugs paying particular attention to how this relates to their action at the appropriate cellular targets. Methods for studying and affecting a drug’s ADME will be examined, e.g. prodrugs, Log P etc.

J E McKendrick (8 lectures) Aspects of Mechanism in Biology
A study of selected primary metabolic pathways of the cell with particular reference to correlation of enzymatic processes to organic chemical mechanisms. Understanding glucose metabolism will lead to an appreciation of how nature uses the principles of Organic and Physical chemistry in the catabolic and anabolic processes. The interrelationship of biochemical pathways, interdiction with drugs after the first committed step of a pathway and the problems and advantages of biochemical feedback.

Brief description of teaching and learning methods:
Two one hour lectures per week (one per topic) with approximately two hours of workshop/seminars in the spring term on related material. The lecture hours in the Summer Term are for revision.

Contact hours:
  Autumn Spring Summer
Lectures 16 2
Seminars 4
Guided independent study 78
       
Total hours by term 94.00 4.00 2.00
       
Total hours for module 100.00

Summative Assessment Methods:
Method Percentage
Written exam 80
Oral assessment and presentation 20

Other information on summative assessment:
One assessed seminar presentation and report on a topic of relevance to the course. The seminar presentations and report will count for 20% of the module mark. The assessment will be set during the Autumn Term and assessment will take place in the Spring Term.

Written Exam 80%

The two hours in the summer term will be allocated to revision.

Formative assessment methods:

Penalties for late submission:
The Module Convenor will apply the following penalties for work submitted late, in accordance with the University policy.

  • where the piece of work is submitted up to one calendar week after the original deadline (or any formally agreed extension to the deadline): 10% of the total marks available for the piece of work will be deducted from the mark for each working day (or part thereof) following the deadline up to a total of five working days;
  • where the piece of work is submitted more than five working days after the original deadline (or any formally agreed extension to the deadline): a mark of zero will be recorded.

  • The University policy statement on penalties for late submission can be found at: http://www.reading.ac.uk/web/FILES/qualitysupport/penaltiesforlatesubmission.pdf
    You are strongly advised to ensure that coursework is submitted by the relevant deadline. You should note that it is advisable to submit work in an unfinished state rather than to fail to submit any work.

    Length of examination:
    1.5 hours

    Requirements for a pass:
    A mark of 40% overall.

    Reassessment arrangements:
    Reassessment will comprise of an examination worth 80% and an oral presentation worth 20%.

    Additional Costs (specified where applicable):
    1) Required text books:
    2) Specialist equipment or materials:
    3) Specialist clothing, footwear or headgear:
    4) Printing and binding: Printing Of Notes Using University Printers Will Cost 5 Pence Per B
    5) Computers and devices with a particular specification:
    6) Travel, accommodation and subsistence:

    Last updated: 21 December 2016

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