** ****DEADLINE APPROACHING: REGISTER HERE BEFORE 26TH MAY!! (SUBMIT TALKS/POSTERS BY 8TH MAY!!)**

On **Friday 7th June 2019** we will be hosting our annual SIAM-IMA Student Chapter Conference at the University of Reading!

This is a student-organised conference for early-career mathematicians. There will be three plenary talks, several student talks and a poster session. Refreshments, including lunch, will be provided and we will go to dinner together afterwards.

The event will bring together PhD students from different universities, giving them the chance to broaden their horizons and see what other students are working on. Furthermore, the conference will give students who are thinking about starting a PhD in mathematics a unique insight into what doing a PhD is like.

**Prof. Nick Trefethen**, University of Oxford

Professor of numerical analysis and head of the Numerical Analysis Group at Oxford, who has made many contributions in both the theory and applications of numerical analysis

**Random Functions, Random ODES and CHEBFUN **

What is a random function? What is noise? The standard
answers are nonsmooth, defined pointwise via the Wiener process
and Brownian motion. In the Chebfun project, we have found it
more natural to work with smooth random functions defined by
finite Fourier series with random coefficients.
The length of the series is determined by a wavelength parameter
lambda. Integrals give smooth random walks, which approach
Brownian paths as lambda shrinks to 0, and smooth random ODEs,
which approach stochastic DEs of the Stratonovich variety.
Numerical explorations become very easy in this framework.

**Prof. Valentina Escott-Price**, Dementia Research Institute, University of Cardiff

Professor in the Medical Research Centre for Neuro-Psychiatric Genetics and Genomics who uses machine learning and bioinformatics for big data problems in genetics and neuroscience

**Predictive modelling from genomic data**

Psychiatric and neurodegenerative disorders have a complex, polygenic architecture in which a large number of genetic variants spanning a wide spectrum of population frequencies contribute to disease risk. In recent years, specific risk variants have begun to emerge from large-scale genomic studies. The standard approach to genome-wide association study (GWAS) data assumes an additive model, which, in statistical terms, is equivalent to looking for the main effects of variants contributing to disease risk. The assumption of additivity has been an extremely effective approach, but it is also pragmatic, since looking at the effects of many 100,000s of Single Nucleotide Polymorphisms (SNPs) would be rendered computationally expensive if all potential combinations of interactions were considered. In addition, the excessive dimensionality of such an approach would require very severe statistical correction for multiple comparison testing. Although testing for some interactions is now technically possible using Graphical Processing Units (GPU) instead of Central Processing Units (CPU), extremely large sample sizes will be required to achieve sufficient power to detect small genetic interaction effect sizes, as are expected in most complex genetic traits, at the very low significance thresholds dictated by multiple testing correction.

The extent to which genetic interactions contribute to disease risk is unknown. We investigated whether a support vector machine learning (SVM) approach can identify the presence of genetic interactions, without explicitly specifying interaction terms in regression models.

Support Vector Machines were introduced by Vapnik and Chervonenkis (1981) and are widely used due to their flexibility in analysing data with different distributions and their ability to deal with high-dimensional data such as gene expression. Previously SVMs using genetic variants as predictors were employed for the classification of populations. We illustrated the use genetic variants to distinguish schizophrenia patients from controls, where genetic differences between the groups are more subtle than between populations, and compared the results with Polygenic Risk Scores and Multivariate regression approaches.

**Dr. Karl-Mikael Perfekt**, University of Reading

Lecturer of Pure Mathematics, working in operator theory, complex analysis, and spectral theory, recent winner of 2018 Zemánek prize in functional analysis, awarded by IMPAN

**The spectrum of double layer potentials for some 3D domains with corners and edges**

I will talk about the spectrum of double layer potential operators for 3D surfaces with rough features. The existence of spectrum reflects the fact that transmission problems across the surface may be ill-posed for (complex) sign-changing coefficients. The spectrum is very sensitive to the regularity sought of solutions. For L^2 boundary data, for domains with corners and edges, the spectrum is complex and carries an associated index theory. Through an operator-theoretic symmetrisation framework, it is also possible to recover the initial self-adjoint features of the transmission problem – corresponding to H^{1/2} boundary data – in which case the spectral picture is more familiar.

It would be great if you could join us! There is no registration fee, but registration is required and we will provide lunch for all registered participants. Please register by **26th May**.

We strongly encourage students to submit an title for a 20 minute talk or a poster presentation by **8th May**. We will contact you if your submission is successful. Thanks to our sponsors, there is limited funding to cover the travel (up to £50) and/or childcare expenses for speakers. There might be a possibility to support poster presenters as well.

We will finish the day with a drinks reception and a self-funded conference dinner.

Thank you to our sponsors, SIAM, IMA and LMS for making this conference possible.

The schedule for the day will be posted at a later date.

The conference will take place in Slingo lecture theatre in the JJ Thompson Building on the Whiteknights campus of the University of Reading. Informations about how to get to Reading and the campus can be found **here**.
A map of the campus can be found ** here**. JJ Thompson is building 3.