Staff Profile:Dr Sakthivel Vaiyapuri

Name::
Position / Job Title:
Lecturer
Responsibilities:
Areas of Interest:

My research interests are mainly focussed on understanding the orchestrated functions of adhesive molecules in the regulation of cellular interactions during the development of inflammatory responses. Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding and however, their inappropriate activation under pathological conditions leads to thrombosis resulting in heart attacks and strokes. My recent successes in platelet research involve the discovery of a new phenomenon of intercellular communication through gap junctions between circulating platelets and their importance for the coordinated function within blood clots. In addition, I have also been involved in the investigation of the importance of Eph-ephrin mediated contact-dependent and independent signalling in the regulation of initial platelet activation and architecture of thrombus. Although platelets play an important role in the maintenance of haemostasis and thrombosis, they are known to be involved in the development of inflammatory responses. Therefore, I am currently investigating the orchestrated functions of adhesive molecules present on the surface of blood cells such as platelets, monocytes and neutrophils and endothelial cells on the inner lining of blood vessels in the regulation of multicellular interactions and their importance during inflammatory responses.

On the other hand, I am also interested in understanding the pathophysiological functions of snake venom proteins in order to improve the diagnostic and therapeutic approaches for snakebites. Since viper venom components are haemotoxic in nature and target the blood coagulation system, I was able to inter-relate the venom proteins with the coagulation system to understand their mechanisms of action. Indeed, I have purified several toxic venom proteins including a snaclec, rhinocetin from the venom of Bitis gabonica rhinoceros which was characterised to be a selective inhibitor of integrin α2β1 on the surface of platelets and endothelial cells. I am currently involved in the expression and molecular characterisation of snake venom proteins from plant-based bioreactors. In addition, I am exploring the therapeutic applications of chemical-based inhibitors as an alternative option for treating snakebites.

Research groups / Centres:
Publications:
Dr Sakthi Vaiypuri

Contact Details

Email:
s.vaiyapuri@reading.ac.uk
Telephone:
+44 (0)118 378 8015
Building:
207 Hopkins

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