Staff Profile:Dr Simon Clarke

Name::
Position / Job Title:
Associate Professor in Cellular Microbiology
Responsibilities:
Areas of Interest:

The research carried out in my laboratory is aimed at understanding how two important human pathogens, Staphylococcus aureus and Streptococcus pyogenes, are able to colonise the human host, resist its defences and cause disease.  I am particularly interested in the effect that surface structures have on the physical properties of bacteria and how this influences the host-pathogen interaction.

In collaboration with our gut microbial ecologist colleagues in the School of Food Biosciences, we are currently investigating the ability of S. aureus to colonise and persist within the human gut.

Research groups / Centres:
Publications:

Clarke SR, Foster SJ. 2008. IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin. Infection and Immunity. In Press.

Clarke SR, Mohamed R, Bian L, Routh AF, Kokai-Kun JF, Mond JJ, Tarkowski A, Foster SJ. 2007. The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin. Cell Host and Microbe. 1:199-212. PubMed

Tiyawisutsri R, Holden MT, Tumapa S, Rengpipat S, Clarke SR, Foster SJ, Nierman WC, Day NP, Peacock SJ. 2007. Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. BMC Microbiology. 7:19.PubMed

Clarke SR, Foster SJ. 2006. Surface adhesins of Staphylococcus aureus. Advances in Microbial Physiology. 51:187-224. PubMed

Pourmand MR, Clarke SR, Schuman RF, Mond JJ, Foster SJ. 2006. Identification of antigenic components of Staphylococcus epidermidis expressed during human infection. Infection and Immunity. 74:4644-4654. PubMed

Clarke SR, Brummell KJ, Horsburgh MJ, McDowell PW, Syed Mohamad SA, Stapleton MR, Acevedo J, Read RC, Day NP, Peacock SJ, Mond JJ, Kokai-Kun JF, Foster SJ. 2006. Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. Journal of Infectious Diseases. 193:1098-1108. PubMed

Clarke SR, Wiltshire MD, Foster SJ. 2004. IsdA of Staphylococcus aureus is a broad spectrum, iron-regulated adhesin. Molecular Microbiology. 51:1509-1519.PubMed

Clarke SR, Harris LG, Richards RG, Foster SJ. 2002. Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus. Infection and Immunity. 70:6680-6687. PubMed

Clarke SR, Dyke KG. 2001. The signal transducer (BlaRI) and the repressor (BlaI) of the Staphylococcus aureus beta-lactamase operon are inducible. Microbiology. 147:803-810.PubMed

Clarke SR, Dyke KG. 2001. Studies of the operator region of the Staphylococcus aureus beta-lactamase operon. Journal of Antimicrobial Chemotherapy. 47:377-389.PubMed

Contact Details

Email:
s.r.clarke@reading.ac.uk
Telephone:
+44 (0) 118 378 8895

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