Staff Profile:Dr Paula Jauregi

Name:

Dr Paula Jauregi

Job Title:

Lecturer

Responsibilities:

Teaching:

- Module convenor for several modules of the Biotechnology programme

-Tutor for 13 tutees

-Department coordinator of innovative teaching techniques and learning technologies for department

-Supervising laboratory research projects of undergraduates (4) and postgraduates (2)

Research:

-Manager of laboratory research group with 4 PhD students

Areas of Interest:

I am a Chemist specialised in Bioseparations.Also I have significant expertise in the fundamentals of gas-liquid dispersions and interfacial phenomena in gas-liquid and liquid-liquid systems. During my PhD I developed a novel technique, colloidal gas aphrons (CGA), based on the formation of gas-liquid dispersions to separate proteins. Also while working at the TU Delft as a post-doctoral researcher I developed a novel method for the separation of solid bioproducts such as semi-synthetic penicillins. Investigations during this period led to the application and filing of a patent. I am generally interested in bioprocessing of bioactive products and their application as functional food ingredients and/or drugs such as food protein derived bioactive peptides. These are the main research projects I am currently developing:

-Enzymatic production of bioactive peptides from whey

• 'Enzymatic production of ACE-inhibitory peptides from b-lactoglobulin' PhD sponsored by Connacyt, Mexico and Amano enzymes (October 04/08)
• Industrial CASE BBSRC studentship with Kerry Foods (October 2008/ 2012)

-Separation of value added proteins from whey by ion exchange membranes

• PhD sponsored by BBSRC-CASE with Volac plc. (August 05/08)

-Recovery of carotenoids from fermentation broth

• 'Recovery of astaxanthin from fermentation broth by colloidal gas aphrons'PhD studentship sponsored by The University of Reading (RETF) and Tate & Lyle plc. (October 05/08)

• PhD sponsored by Thai Government (2008/11)

-Production and purification of biosurfactants from Bacillus subtillis

• 'Recovery and purification of surfactin from Bacillus subtillis fermentation by a two-step ultrafiltration process' and a PhD sponsored by Malasyan Government (May 05/08)
• On-going research collaboration with Lille University (France)

-Recovery of value added products from wine waste

Collaboration started with the University of Piacenza (Italy) on recovery of polyphenols from wine waste extracts by CGA – British Council Award (December 2007/08)

Research groups / Centres:

Publications:

Jauregi, P. and Varley, J. 1999. Colloidal gas aphrons: potential applications in biotechnology. Trends in Biotechnology 17: 389-395.

Jauregi, P. and Varley, J. 2000. Colloidal gas aphrons (CGA): dispersion and structural features. American Institution of Chemical Engineers Journal, 46(1): 24-36.

Jauregi, P., Hoeben, M. A., van der Lans, R. G. J. M., Kwant, G. and van der Wielen, L. A. M. 2001. Selective separation of physically near-identical micro-particle mixtures by interfacial partitioning. Industrial and Engineering Chemistry Research, 10: 5815-5821.

Jauregi, P., Hoeben, M. A., van der Lans, R. G. J. M., Kwant, G. and van der Wielen, L. A. M. 2002.Recovery of small bioparticles by interfacial partitioning. Biotechnology and Bioengineering78(4): 355-364.

Fuda. E, Jauregi P., and Pyle, D. L. 2004. Recovery of Lactoferrin and Lactoperoxidase from Sweet Whey Using Colloidal Gas Aphrons (CGAs) Generated from an Anionic Surfactant, AOT. Biotechnology Progress, 20(2): 514-525.

Fuda. E, Bhatia D., Pyle, D.L, and Jauregi, P. 2005. Selective separation of b-lactoglobulin from sweet whey using CGAs generated from the cationic surfactant CTAB. Biotechnology and Bioengineering, 90:532-542.

Wissmann-Alves R., Ulson de Souza A.A., de Arruda Guelli Ulson de Souza, S. M. and Jauregi P. 2006. Recovery of Norbixin from a Raw Extraction Solution of Annatto Pigments using Colloidal Gas Aphrons (CGAs). Separation and Purification Technology, 48(2): 208-213.

Recovery of polyphenols from wine-making wastes with colloidal gas-aphrons (CGA). Spigno, G. And Jauregi, P. 2005.International Journal of Food Engineering 1(4)

Fuda. E, and Jauregi, P. 2006. An insight into the mechanism of protein separation by colloidal gas aphrons (CGA) generated from ionic surfactants. J.Chromatography B, 843, 317-326

Recovery and purification of surfactin from fermentation broth by a two-step ultrafiltration process. Isa, M. H.M., Coraglia, D. E., Frazier, R. A. and Jauregi P. 2007. Journal of Membrane Science, Journal of Membrane Science, 296: 51-57.

Complex Formation of Bovine Serum Albumin with a Poly(ethylene glycol) Lipid ConjugateCastelletto V., Kelarakis, A., Krysmann, M., Jauregui, P. Biomacromolecules ,8 (7): 2244 -2249, 2007.

Dermiki, M., Gordon M H, Jauregi, P. The use of colloidal gas aphrons as novel downstream processing for the recovery of astaxanthin from cells of Phaffia rhodozyma
Maria, Journal of Chemical Technology and Biotechnology, Published Online: Jan 7 2008 9:56AM
DOI: 10.1002/jctb.1855

Goodall, S., Grandison., A. S., Jauregi, P. and Price, J.Selective separation of the major whey proteins using ion exchange membranes" Journal of Dairy Science, DOI: 10.3168/jds.2007-0539

Book Chapter:  Ortiz-Chao P, and Jauregi P. 2007. Enzymatic production of bioactive peptides from milk and whey proteins. In: Rastall RA, editor. Novel enzyme technology for food applications. Cambridge: Woodhead Publishing Ltd.

Patent:

Jauregi, P., Hoeben, M. A., van der Lans, R. G. J. M., Kwant, G. and van der Wielen, L. A. M.

Qualifications:

BSc in Chemistry with specialisation in Organic Chemistry, Biochemistry and Chemical Engineering, Department of Chemical Sciences, The University of the Basque Country, Spain
PhD in ‘Colloidal gas aphrons (CGA): a novel approach to protein recovery’, School of Food Biosciences, The University of Reading, England
Fellow in Further Professional Studies in Higher Education and I am a member of the Higher Education Academy.
I am a member of the Society of Chemistry and Industry and I am a committee member of the Separation Science and Technology Group. As a committee member I organised a one day international conference on ‘Separations of Value Added Products in the Food Industry’ (30th March, at SCI headquarters, London).
I am also a member of the Fluids Separations Subject Group of the Institution of Chemical Engineers.

Research Awards

Nuffield Fund (March 2002)

Fast track Food Faraday awards (October 2004/2005 and October 2007/08); Fast Track Faraday programme project award winner (November 05)

British Council award-British Italian partnership programme (December 07/08)