Staff Profile:Dr Kim Jackson

Name:

Dr Kim Jackson

Job Title:

Research Fellow

Responsibilities:

Senior Research Fellow

Areas of Interest:

Impact of diet, in particular dietary fatty acids on cardiovascular disease

Effects of meal fatty acids on the metabolism of postprandial triacylglycerol-rich lipoproteins

Influence of genotype on cardiovascular disease risk

Meal fatty acids and postprandial vascular reactivity

Development of mathematical models of postprandial lipoprotein metabolism

Research groups / Centres:

Publications:

Peer reviewed publications (2000-2008)

Rimbach G, Jofre-Monseny L, Huebbe P, Stange I, Boesch-Saadatmandi C, Frank J, Jackson K and Minihane A (2008). Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein in apoE3 and apoE4 targeted replacement mice. British Journal of Nutrition 100, 44-53.

Armah CK, Jackson KG, James L, Doman I, Cheghani F and Minihane AM (2008). Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clinical Science 114, 679-686.

Bateman PA, Jackson KG, Maitin V, Yaqoob P and Williams CM (2007). Differences in cell morphology, lipid and apo B secretory capacity in caco-2 cells following long term treatment with saturated and monounsaturated fatty acids. Biochimica et Biophysica Acta 1771, 475-485.

Jackson KG, Wolstencroft EJ, Bateman PA, Yaqoob P and Williams CM (2006). Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids. Nutrition, Metabolism and Cardiovascular Diseases. 16, 405-417.

Jackson KG, Maitin V, Leake DS, Yaqoob P and Williams CM (2006). Saturated fat induced changes in S_f 60-400 particle composition reduces uptake of LDL by HepG2 cells.Journal of Lipid Research 47, 393-403.

Jackson KG, Wolstencroft EJ, Bateman PA, Yaqoob P and Williams CM (2005). Acute effects of meal fatty acids on postprandial NEFA, glucose and apolipoprotein E response: implications for insulin sensitivity and lipoprotein regulation? British Journal of Nutrition 93, 693-700

Palmer AM, Nova E, Anil E, Jackson K, Bateman P, Wolstencroft E, Williams CM and Yaqoob P (2005). Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages. Atherosclerosis 180, 233-244.

Jackson KG, Wolstencroft EJ, Bateman PA, Yaqoob P and Williams CM (2005). Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acids. American Journal of Clinical Nutrition 81, 25-34.

Jackson KG, Knapper-Francis JME, Morgan LM, Webb DH, Zampelas A and Williams CM (2003), Exaggerated postprandial lipaemia and lower postheparin lipoprotein lipase activity in middle-aged men. Clinical Science, 105, 457-466.

Robertson MD, Parkes M, Warren BF, Ferguson DJP, Jackson KG, Jewell DP and Frayn KN (2003), Mobilization of enterocyte fat stores by oral glucose in man. Gut 6, 833-838.

Robertson MD, Jackson KG, Fielding BA, Morgan LM, Williams CM and Frayn KN (2002), Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women. British Journal of Nutrition 88, 635-640.

Jackson KG, Robertson MD, Fielding BA, Frayn KN and Williams CM (2002), Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed. American Journal of Clinical Nutrition 76, 942-949.

Jackson KG, Robertson MD, Fielding BA, Frayn KN and Williams CM (2002), Measurement of apolipoprotein B-48 in the Svedberg flotation rate (S_f)>400, S_f 60-400 and S_f 20-60 lipoprotein fractions reveal novel findings with respect to the effects of dietary fatty acids on triacylglycerol-rich lipoproteins in postmenopausal women. Clinical Science 103, 227-237.

Robertson MD, Jackson KG, Fielding BA, Morgan LM, Williams CM and Frayn KN (2002), Acute ingestion of triacylglycerol rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying. American Journal of Clinical Nutrition 76, 232-237.

Jackson KG, Robertson MD, Fielding BA, Frayn KN and Williams CM (2001), Second meal effect: modified sham feeding does not provoke the release of stored triacylglycerol from a previous high-fat meal. British Journal of Nutrition 85, 149-156.

Robertson MD, Jackson KG, Fielding BA, Williams CM and Frayn KN (2001), Prolonged effects of modified sham feeding on energy substrate mobilization. American Journal of Clinical Nutrition 73, 111-117.

Jackson KG, Zampelas A, Knapper JME, Roche HM, Gibney MJ, Kafatos A, Gould BJ, Wright JW and Williams CM (2000), Differences in glucose dependent insulinotrophic polypeptide hormone and hepatic lipase in subjects of southern and northern Europe: implications for postprandial lipemia? American Journal of Clinical Nutrition 71, 13-20.

Invited Reviews

Jackson KG, Armah CK and Minihane AM (2007). Meal fatty acids and postprandial vascular reactivity. Biochemical Society Transactions 35, 451-453.

Fava F, Lovegrove JA, Gitau R, Jackson KG and Tuohy KM (2006). The gut microbiota and lipid metabolism: implications for human health and coronary heart disease. Current Medicinal Chemistry 13, 3005-3021.

Williams CM, Maitin V and Jackson KG (2004)Triglyceride-rich lipoprotein-gene interaction in endothelial cells. Biochemistry Society Transactions 32, 994-998.

Jackson KG and Lovegrove JA (2004) Functional food, blood lipids and
cardiovascular disease. Part 2 – Prebiotics and Synbiotics. AgroFOOD Industry HiTech 15(2), 37-39.

Lovegrove JA and Jackson KG (2004) Functional food, blood lipids and
cardiovascular disease. Part 1 - Probiotics. AgroFOOD Industry HiTech 15(1),
50-52.

Williams CM, Bateman PA, Jackson KG and Yaqoob P (2004), Dietary fatty acids, chylomicron synthesis and secretion. Biochemistry Society Transactions. 32, 55-58.

Jackson KG and Williams CM (2004) Apolipoprotein B-48: comparison of fasting concentrations in normolipidaemic individuals using SDS-PAGE, immunoblotting and ELISA. Invited commentary for the International Atherosclerosis Society website http://www.athero.org

Jackson KG and Williams CM (2004) Apolipoprotein B-48: comparison of fasting concentrations in normolipidaemic individuals using SDS-PAGE, immunoblotting and ELISA. Atherosclerosis. 176, 207-217.

Williams CM and Jackson KG (2002), Inulin and oligofructose: effects on lipid metabolism from human studies. British Journal of Nutrition87 (Suppl. 2) S261-S264.

Jackson KG and Lovegrove JA. Functional foods, blood lipids and coronary heart disease. Food science and technology bulletin 1, 1-11. IFIS publishing 2002.

http://www.foodsciencecentral.com/library.html#ifis/3965.

Book Chapters

Lovegrove J and Jackson K. Coronary Heart Disease. In: Functional Dairy Products, Mattila-Sandholm T and Saarela M, eds. Woodhead Publishing Limited, Cambridge, England (2003)

Lovegrove JA and Jackson KG. Coronary Heart Disease. In: Functional Foods: Concept to Product, Gibson GR and Williams CM, eds. Woodhead Publishing Limited, Cambridge, England (2000).

Qualifications:

BSc (Hons) Biochemistry, School of Biological Sciences, University of Surrey.
PhD (Nutrition and Biochemistry), School of Biological Sciences, University of Surrey

Member of the Nutrition Society and Biochemical Society