Staff Profile:Dr. George Grimble

Responsibilities:

Reader in Clinical Nutrition

Areas of Interest:

I am a biochemist and nutritionist with a general interest in gastrointestinal physiology and in the "dark-side" of nutrition, or clinical nutrition as it is also known. The key questions are "What effect does disease have on nutrition status?" and, most importantly, "How can we use nutrition support to improve clinical outcome?" My special interests relate to Research into metabolic outcomes and processes in critical illness in neonates and in adult patients. Inflammatory bowel disease Use of biomarkers of progression of critical and chronic illness and the effect of nutrition support on this (e.g. markers of RNA and glycogen turnover and inflammation). Nutrition and the elderly and effects of illness on taste and appetite.

Research groups / Centres:

 

Collaborator on Grant "Taste Enhancement of Food for Elderly Individuals aiming to Increase Food Intake " – Dr Lisa Methven, Principle Investigator. £142,000

Publications:

number of edited books: 6

full research papers: 51

review articles: 90

published abstracts: ca.100

patents: 2

1992 – 1999Founding Editor, Current Medical Literature - Clinical Nutrition

1990 – 2006Associate Editor, British Journal of Intensive Care

2004 - 2006Theme Leader for Clinical Nutrition & Metabolism - Nutrition Society

1996 - 2006Nutrition and Metabolism Steering Group of the European Society of Intensive Care Medicine

1994 - 2006Scientific Advisory Committee of the Nutricia Research Foundation, Chair 2001-2006.

Recent books

Payne-James JJ, Grimble GK, Forbes A & Silk DBA (2008) Artificial Nutrition Support in Clinical Practice (3^rd edition). Cambridge: Cambridge University Press.

Recent peer-reviewed papers

Culkin A, Gabe SM, Bjarnason I, Grimble G, Madden AM & Forbes A (2007) A double-blind, randomized, controlled crossover trial of glutamine supplementation in home parenteral nutrition. Eur J Clin Nutr. Apr 18; [Epub ahead of print]

Goulas AK, Fisher DA, Grimble GK, Grandison AS & Rastall RA (2004) Synthesis of isomaltooligosaccharides and oligodextrans by the combined use of dextransucrase and dextranase. Enzyme Microb Technol 35, 327-338.

Taylor RM, Preedy VR, Baker AJ & Grimble G (2003) Nutritional support in critically ill children. Clin Nutr 22, 365-369.

Recent reviews and book chapters

Grimble GK (2007) Adverse gastrointestinal effects of arginine and related amino acids. J Nutr 137, 1S-9S.

Grimble G (2005) The physiology of nutrient digestion and absorption. In Human Nutrition, pp. 49-64 [C Geissler and H Powers, editors]. Edinburgh: Elsevier Churchill Livingstone.

Grimble GK (2004) Quantitative and qualitative aspects of nitrogen supply in enteral nutrition in relation to free amino acids and peptides. In Amino acid metabolism in health and nutritional diseases, pp. 529-556 [L Cynober, editor]. Boca Raton: CRC Press.

Biolo G, Grimble G, Preiser JC, Leverve X, Jolliet P, Planas M, Roth E, Wernerman J & Pichard C (2002) Position paper of the ESICM Working Group on Nutrition and Metabolism: Metabolic basis of nutrition in intensive care unit patients: ten critical questions. Intensive Care Med 28, 1512-1520.

Grimble GK & Westwood OMR (2000) Nucleotides and immunity. In Nutrition and Immunity, pp. 135-144 [ME Gershwin, B German, and CL Keen, editors]. Totowa, NJ: Humana Press Inc.

Grimble GK, Malik SB & Boza JJ (2000) Methods for measuring tissue RNA turnover. Curr Opin Clin Nutr Metab Care 3, 399-408.

Grimble GK (2000) Mechanisms and regulation of peptide and amino acid transport. In Proteins, Peptides and Amino-Acids in Enteral Nutrition, pp. 63-88 [P Fürst and VR Young, editors]. Basel: S Karger AG.

Qualifications:

BSc, PhD

Honorary Senior Lecturer, Department of Gastroenterology & Nutrition, Division of Medicine, University College London

Visiting Professor, St George's Medical School, Grenada