Staff Profile:Dr Chris Smith

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  • Lecturer in Organic Chemistry

Building/Room: Chemistry/110


Dr Smith's research is directed towards new applications of synthetic chemistry where he has a long-standing interest in the development of new transition metal based catalytic methods. The harnessing of base metals such as Fe, Co, Ni or Cu is particularly attractive due to their unusual reactivities and low-cost compared to Pd Rh or Ir.

Fluorine is ubiquitous to modern life ranging from plastics through to drugs and agrochemicals. We continue to investigate new routes and reagents for the incorporation of this important element.

Finally, we have a great deal of experience in continuous flow with applications ranging from drug syntheses and multi-phase reactions, through to nano-particle syntheses. We are looking forward to applying this technology across the disciplines.

Peer-reviewed journal articles

14) Methyl Hydrazinocarboxylate as a Practical Alternative to Hydrazine in the Wolff-Kishner Reaction.
P. B. Cranwell, Andrew T. Russell, Christopher D. Smith, Synlett, 2015, DOI: 10.1055/s-0035-1560805.

13) Investigation of Petasis and Ugi reactions in series in an automated microreactor system.
N. Heublein, J. S. Moore, C. D. Smith and K. F. Jensen
RSC Adv., 2014, 4, 63627-63631.

12) Zinc Mediated Azide-Alkyne Ligation to 1,5- and 1,4,5-Substituted 1,2,3-Triazoles.
C. D. Smith and M. F. Greaney
Org. Lett., 2013, 15, 4826-4829.

11) In situ formation of azides and their reaction with monolithic supported triphenylphosphine under flow conditions.
C. J. Smith, N. Nikbin, C. D. Smith, I. R. Baxendale and S. V. Ley
Org. Biomol. Chem. 2011, 9, 1927-1937.

10) Sequential oxidation/Seyferth-Gilbert/CuAAC reactions performed with a modular flow reactor.
I. R. Baxendale, S. V. Ley, A. Mansfield and C. D. Smith
Angew. Chem., Int. Ed. 2009, 48, 4017-4021.

9) New opportunities for advancing organic synthesis and flow based chemical processing.
M. Baumann, I. R. Baxendale, J. J. Hayward, M. D. Hopkin, J. Jin, M. O. Kitching, S. Lanners, S. V. Ley, N. Nikbin-Rousardi, C. D. Smith, C. J. Smith and L. Tamborini
J. Labelled Compd Rad. 2008, 51, 252-253.

8) A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.
I. R. Baxendale, S. V. Ley, C. D. Smith, L. Tamborini and A.-F. Voica
J. Comb. Chem. 2008, 10, 851-857.

7) Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions.
M. Baumann, I. R. Baxendale, S. V. Ley, N. Nikbin and C. D. Smith
Org. Biomol. Chem. 2008, 6, 1587-1593.

6) A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
M. Baumann, I. R. Baxendale, S. V. Ley, N. Nikbin, C. D. Smith and Jason P. Tierney
Org. Biomol. Chem. 2008, 6, 1577-1586.

5) Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor.
C. D. Smith, I. R. Baxendale, G. K. Tranmer, M. Baumann, S. C. Smith, R. A.
Lewthwaite and S. V. Ley
Org. Biomol. Chem. 2007, 5, 1562-1568.

4) [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.
C. D. Smith, I. R. Baxendale, S. Lanners, J. J. Hayward, S. C. Smith and S. V. Ley,
Org. Biomol. Chem. 2007, 5, 1559-1561.

3) A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
I. R. Baxendale, S. V. Ley, C. D. Smith and G. K. Tranmer,
Chem. Commun. 2006, 4835-4837.

2) Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles.
M. Baumann, I. R. Baxendale, S. V. Ley, C. D. Smith and G. K. Tranmer,
Org. Lett. 2006, 8, 5231-5234.

1) Synthesis of linked heterocycles via use of bis-acetylenic compounds.
C. D. Smith, K. Tchabanenko, R. M. Adlington and J. E. Baldwin
Tetrahedron Lett. 2006, 3209-3212.

Book Chapter

'Heterogeneous Reactions' in Microreactors in Organic Synthesis and Catalysis.
J. J. Hayward, S. Lanners, I. R. Baxendale, S. V. Ley and C. D. Smith
Ed. T. Wirth, Wiley-VCH: Weinheim, 2008, pp. 84-122.

 

Chris Smith photo

Contact Details

Email:

c.d.smith@reading.ac.uk

 

Telephone:
+ 44 (0) 118 378 6312

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