Viral Pathogens

virusesThis module studies the interaction of viruses with the whole organism at the molecular level with the aim of understanding how viruses cause disease. The "big killers" are all here, Influenza, HIV, viruses that cause hepatitis and hemorrhagic fevers. The module includes coverage of viral tropisms, the role of the immune response in viral pathogenesis, strategies adopted by viruses to evade the host immune response and the emergence of new virus strains. The module consists of a series of lectures augmented by two PBL sessions where students debate issues of interest to the wider virology community including forming an opinion on the benefit or not of vaccination.


JonesIan_largeProfessor Ian Jones is a virologist with a particular interest in how proteins, mostly viral proteins, carry out the functions for which they have evolved and how this activity contributes to the virus life cycle. He works on a number of viruses including retroviruses (HIV and MLV), hepaciviruses (hepatitis C virus) and baculoviruses (Autographa californica MNPV). Although these virus models are diverse, they share certain activities which are probably mechanistically related. For example, all are enveloped viruses and must fuse with the cell membrane in order to deliver their nucleic acid and formally begin an infectious cycle. The more we understand about what happens when a virus docks with, and then enters, a cell, the better our chance of preventing it.

Module convenor: Professor Ian Jones

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