Staff Profile:Dr Tamara Gritsun

Name:

Dr Tamara Gritsun

Job Title:

Academic, AMS Building

Responsibilities:

Areas of Interest:

Research Interests:

Molecular virology, molecular pathogenesis and evolution, molecular mechanisms of virus replication and adaptation to the environment.

The main interest in my group is tick-borne flaviviruses (TBFV), a genetically closely related pathogens that infect and are transmitted to humans and animals by infected ticks. Despite the close antigenic and genetic relationships, these viruses produce a variety of clinical manifestations that include asymptomatic infections, fevers, haemorrhagic disease, encephalitis and chronic diseases. We have developed a genetic system based on infectious clones of Tick-borne encephalitis virus, to study the molecular basis of virus pathogenesis and vector transmission and also to develop attenuated virus variants that could be used as the basis to develop a live attenuated vaccine. Recently we initiated a research on secondary RNA structures of flaviviruses that are the primary sites for interaction with viral and cellular proteins to form virus replication complexes, and their significance in the virus adaptation to vertebrate and invertebrate hosts.Finally, we use molecular epidemiological techniques to study virus taxonomy and evolution.

Currently Funded Research Projects:

BBSRC, 2004-2008. "Development of engineered chimaeric tick-borne flaviviruses to study the molecular basis of virus transmission between co-feeding ticks".

EU 6^th Framework Structural Genomics "Comparative Structural Genomics of Viral Enzymes Involved in Replication (VIZIER)"

INTAS PhD studentship, 2006-2008. "Use of novel proteomic methods to identify cellular receptors for tick-transmitted flaviviruses in tick and mammalian hosts"

Research groups / Centres:

Microbiology research group

Publications:

Y

Jump to: 2011 | 2009 | 2008 | 2007

Number of items: 10.

2011

• Tuplin, A., Evans, D. J., Buckley, A., Jones, I. M., Gould, E. A. and Gritsun, T. S. (2011) Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus. Nucleic Acids Research. ISSN 1362-4962 doi: 10.1093/nar/gkr237 (In Press)

2009

• Ruzek, D., Salat, J., Palus, M., Gritsun, T. S., Gould, E. A., Dykova, I., Skallova, A., Jelinek, J., Kopecky, J. and Grubhoffer, L. (2009) CD8+ T-cells mediate immunopathology in tick-borne encephalitis. Virology, 384 (1). pp. 1-6. ISSN 0042-6822 doi: 10.1016/j.virol.2008.11.023
• Khasnatinov, M. A., Ustanikova, K., Frolova, T. V., Pogodina, V. V., Bochkova, N. G., Levina, L. S., Slovak, M., Kazimirova, M., Labuda, M., Klempa, B., Eleckova, E., Gould, E. A. and Gritsun, T. S. (2009) Non-hemagglutinating flaviviruses: molecular mechanisms for the emergence of new strains via adaptation to European ticks. Plos One, 4 (10). p. 11. ISSN 1932-6203 doi: 10.1371/journal.pone.0007295
• Gould, E.A., Coutard, B., Malet, H., Morin, B., Jamal, S., Weaver, S., Gorbalenya, A., Moureau, G., Baronti, C., Delogu, I., Forrester, N., Khasnatinov, M., Gritsun, T., de Lamballarie, X. and Canard, B. (2009) Understanding the alphaviruses: Recent research on important emerging pathogens and progress towards their control. Antiviral Research, 87 (2). 111-124 . ISSN 0166-3542 doi: 10.1016/j.antiviral.2009.07.007

2008

• Ruzek, D., Gritsun, T. S., Forrester, N. L., Gould, E. A., Kopecky, J., Golovchenko, M., Rudenko, N. and Grubhoffer, L. (2008) Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus. Virology, 374 (2). pp. 249-255. ISSN 0042-6822 doi: 10.1016/j.virol.2008.01.010
• Gritsun, T.S. and Gould, E. A. (2008) Tick-bourne encephalitis Viruses (Flaviviridae). In: Encyclopedia of Virology. Elsevier, pp. 45-54. ISBN 9780123744104

2007

• Gritsun, T. S. and Gould, E. A. (2007) Direct repeats in the flavivirus 3' untranslated region; a strategy for survival in the environment? Virology, 358 (2). pp. 258-65. ISSN 0042-6822 doi: 10.1016/j.virol.2006.09.033
• Grard, G., Moureau, G., Charrel, R. N., Lemasson, J. J., Gonzalez, J. P., Gallian, P., Gritsun, T. S., Holmes, E. C., Gould, E. A. and de Lamballerie, X. (2007) Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology, 361 (1). pp. 80-92. ISSN 0042-6822 doi: 10.1016/j.virol.2006.09.015
• Gritsun, T. S. and Gould, E. A. (2007) Origin and evolution of 3'UTR of flaviviruses: long direct repeats as a basis for the formation of secondary structures and their significance for virus transmission. Advances in Virus Research, 69. pp. 203-48. ISSN 0065-3527 doi: 10.1016/S0065-3527(06)69005-2
• Gritsun, T. S. and Gould, E. A. (2007) Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications? Virology, 366 (1). pp. 8-15. ISSN 0042-6822 doi: 10.1093/icb/icm026

This list was generated on Fri May 25 01:17:07 2012 BST.