Staff Profile:Dr Simon Clarke

Name:

Dr Simon Clarke

Job Title:

Academic, AMS Building

Responsibilities:

Areas of Interest:

The research carried out in my laboratory is aimed at understanding how two important human pathogens, Staphylococcus aureus and Streptococcus pyogenes, are able to colonise the human host, resist its defences and cause disease.  I am particularly interested in the effect that surface structures have on the physical properties of bacteria and how this influences the host-pathogen interaction.

I collaboration with our gut microbial ecologist colleagues in the School of Food Biosciences, we are currently investigating the ability of S. aureus to colonise and persist within the human gut.

Research groups / Centres:

Microbiology research group

Institute for Cardiovascular & Metabolic Research

Publications:

Y

Jump to: 2011 | 2010 | 2009 | 2008 | 2007

Number of items: 9.

2011

• Sannasiddappa, T.H., Costabile, A., Gibson, G. and Clarke, S. (2011) The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system. PloS ONE, 6 (8). E23227. ISSN 1932-6203
• Jackson, R. W., Johnson, L. J., Clarke, S. R. and Arnold, D. L. (2011) Bacterial pathogen evolution: breaking news. Trends in Genetics, 27 (1). pp. 32-40. ISSN 0168-9525 doi: 10.1016/j.tig.2010.10.001

2010

• Clarke, S. R. (2010) Phenol-soluble modulins of Staphylococcus aureus lure neutrophils into battle. Cell Host and Microbe, 7 (6). pp. 423-424. ISSN 1931-3128 doi: 10.1016/j.chom.2010.05.015

2009

• Clarke, S. R., Andre, G., Walsh, E. J., Dufrene, Y. F., Foster, T. J. and Foster, S. J. (2009) Iron-regulated surface determinant protein a mediates adhesion of staphylococcus aureus to human corneocyte envelope proteins. Infection and Immunity, 77 (6). pp. 2408-2416. ISSN 0019-9567 doi: 10.1128/iai.01304-08

2008

• Jensen, R. O., Winzer, K., Clarke, S. R., Chan, W. C. and Williams, P. (2008) Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC. Journal of Molecular Biology, 381 (2). pp. 300-309. ISSN 0022-2836 doi: 10.1016/j.jmb.2008.06.018
• Clarke, S. R. and Foster, S. J. (2008) IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin. Infection and Immunity, 76 (4). pp. 1518-1526. ISSN 0019-9567 doi: 10.1128/IAI.01530-07

2007

• Wright, A. C., Cole, J. M., Newport, R. J., Fisher, C. E., Clarke, S. J., Sinclair, R. N., Fischer, H. E. and Cuello, G. J. (2007) The Neutron Diffraction Anomalous Dispersion Technique and its Application to Sm2O3.4P2O5. Nuclear Instruments & Methods in Physics Research. Section A., 571 (3). pp. 622-635. ISSN 0168-9002 doi: 10.1016/j.nima.2006.11.045
• Tiyawisutsri, R., Holden, M. T., Tumapa, S., Rengpipat, S., Clarke, S. R., Foster, S. J., Nierman, W. C., Day, N. P. and Peacock, S. J. (2007) Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis. BMC Microbiology, 7 (19). p. 19. ISSN 1471-2180 doi: 10.1186/1471-2180-7-19
• Clarke, S.R. , Mohamed, R. , Bian, L. , Routh, A.F. , Kokai-Kun, J.F. , Mond, J.J. , Tarkowski, A. and Foster, S.J. (2007) The staphylococcus aureus surface protein IsdA mediates resistance to the innate defenses of human skin. Cell Host and Microbe, 1 (3). pp. 192-212. ISSN 1931-3128 doi: 10.1016/j.chom.2007.04.005

This list was generated on Thu May 24 18:00:04 2012 BST.

 

Other publications

Jensen RO, Winzer K, Clarke SR, Chan WC, Williams P. (2008) Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC. Journal of Molecular Biology. 381:300-309.

Clarke SR, Foster SJ. (2006) Surface adhesins of Staphylococcus aureus. Advances in Microbial Physiology. 51:187-224.

Clarke SR, Brummell KJ, Horsburgh MJ, McDowell PW, Mohamad SA, Stapleton MR, Acevedo J, Read RC, Day NP, Peacock SJ, Mond JJ, Kokai-Kun JF, Foster SJ. (2006) Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. Journal of Infectious Diseases. 193:1098-1108.

Pourmand MR, Clarke SR, Schuman RF, Mond JJ, Foster SJ. (2006) Identification of antigenic components of Staphylococcus epidermidis expressed during human infection. Infection and Immunity. 74:4644-4654.