Staff Profile:Dr Philippa Darbre

Name:
Dr Philippa Darbre
Job Title:
Associate Professor
Responsibilities:

Associate Professor

  • Programme Advisor for Biochemistry
Areas of Interest:
  • Funding from the Breast Cancer Research Trust
  • Molecular and cellular mechanisms of action of oestrogen and oestrogen-mimicking chemicals in human breast cancer cells
  • Studying cellular and molecular mechanisms by which human breast cancer cells escape from oestrogen regulation of cell proliferation as a model system for investigating the clinical problem of loss of response to endocrine therapy in breast cancer
  • Focus on the effects of long-term low-dose environmental chemicals (alone and in combination) in human breast epithelial cells, especially in relation to how they may influence the hallmarks of cancer
  • Laboratory currently has five postgraduate students, all self-funded from overseas
Member of the Molecular & Cellular Medicine Group
Research groups / Centres:

Impact, Enterprise and Outreach:

  • REF2014 Impact case study: The reduction in the use of potentially toxic chemicals in cosmetics, thus safeguarding human health
  • Research on parabens has led to extensive media coverage and increasing public awareness of the issues surrounding useage of parabens in consumer products.
  • Research on aluminium has led to extensive media coverage and increasing public awareness of issues surrounding use of aluminium-based salts as antiperspirants to control underarm perspiration.
  • Media coverage on cosmetics and breast cancer has been international and includes websites, national/local newspaper and magazine articles, television interviews, documentaries and films.
  • Application of the research on parabens and aluminium by industry has led to the availability of paraben-free and aluminium-free products on supermarket shelves.
  • Research results have been adopted and used by non-government organisations (NGOs)
  • Research results have been featured in numerous websites and in popular books.

Esteem Factors:

  • Scientific Advisor, European Commission-Committee on Health and Environmental Risks
  • Scientific Advisory Board of the International Halifax Project
  • Editorial board member for J. Applied Toxicology, Hormone Molecular Biology and Clinical Investigation
  • Organizer and Plenary Speaker: Hormone Molecular Biology and Clinical Investigation.
  • Member of Organising Committee of the International Meeting of the Journal of Steroid Hormone Biochemistry and Molecular Biology, held in Seefeld, Austria, September 2010
  • External examiner MRes Medical Sciences, University of Newcastle
  • Patron of the charity CancerActive

Teaching:

  • Part 1: Biochemistry and Metabolism*
  • Part 2: Life and Death of a Cell*
  • Part 3: Cancer*, Medical Genetics, Medicinal Plants, Selected Topics in Endocrine Disease

(* Module coordinator)

International Collaborators:

  • Prof F Mannello, University of Urbino, Italy

National Collaborators:

  • Mr L Barr, Genesis Breast Cancer Prevention centre, University Hospital of South Manchester
  • Prof C Exley, University of Keele
Publications:
Y
Jump to: 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003
Number of items: 49.

2015

  • Goodson, W. H., Lowe, L., Carpenter, D. O., Gilbertson, M., Manaf Ali, A., Lopez de Cerain Salsamendi, A., Lasfar, A., Carnero, A., Azqueta, A., Amedei, A., Charles, A. K., Collins, A. R., Ward, A., Salzberg, A. C., Colacci, A., Olsen, A.-K., Berg, A., Barclay, B. J., Zhou, B. P., Blanco-Aparicio, C., Baglole, C. J., Dong, C., Mondello, C., Hsu, C.-W., Naus, C. C., Yedjou, C., Curran, C. S., Laird, D. W., Koch, D. C., Carlin, D. J., Felsher, D. W., Roy, D., Brown, D. G., Ratovitski, E., Ryan, E. P., Corsini, E., Rojas, E., Moon, E.-Y., Laconi, E., Marongiu, F., Al-Mulla, F., Chiaradonna, F., Darroudi, F., Martin, F. L., Van Schooten, F. J., Goldberg, G. S., Wagemaker, G., Nangami, G., Calaf, G. M., Williams, G., Wolf, G. T., Koppen, G., Brunborg, G., Kim Lyerly, H., Krishnan, H., Ab Hamid, H., Yasaei, H., Sone, H., Kondoh, H., Salem, H. K., Hsu, H.-Y., Park, H. H., Koturbash, I., Miousse, I. R., Scovassi, A.I., Klaunig, J. E., Vondráček, J., Raju, J., Roman, J., Wise, J. P., Whitfield, J. R., Woodrick, J., Christopher, J. A., Ochieng, J., Martinez-Leal, J. F., Weisz, J., Kravchenko, J., Sun, J., Prudhomme, K. R., Narayanan, K. B., Cohen-Solal, K. A., Moorwood, K., Gonzalez, L., Soucek, L., Jian, L., D’Abronzo, L. S., Lin, L.-T., Li, L., Gulliver, L., McCawley, L. J., Memeo, L., Vermeulen, L., Leyns, L., Zhang, L., Valverde, M., Khatami, M., Romano, M. F., Chapellier, M., Williams, M. A., Wade, M., Manjili, M. H., Lleonart, M., Xia, M., Gonzalez, M. J., Karamouzis, M. V., Kirsch-Volders, M., Vaccari, M., Kuemmerle, N. B., Singh, N., Cruickshanks, N., Kleinstreuer, N., van Larebeke, N., Ahmed, N., Ogunkua, O., Krishnakumar, P.K., Vadgama, P., Marignani, P. A., Ghosh, P. M., Ostrosky-Wegman, P., Thompson, P., Dent, P., Heneberg, P., Darbre, P., Sing Leung, P., Nangia-Makker, P., Cheng, Q. (S.), Robey, R.B., Al-Temaimi, R., Roy, R., Andrade-Vieira, R., Sinha, R. K., Mehta, R., Vento, R., Di Fiore, R., Ponce-Cusi, R., Dornetshuber-Fleiss, R., Nahta, R., Castellino, R. C., Palorini, R., Abd Hamid, R., Langie, S. A.S., Eltom, S., Brooks, S. A., Ryeom, S., Wise, S. S., Bay, S. N., Harris, S. A., Papagerakis, S., Romano, S., Pavanello, S., Eriksson, S., Forte, S., Casey, S. C., Luanpitpong, S., Lee, T.-J., Otsuki, T., Chen, T., Massfelder, T., Sanderson, T., Guarnieri, T., Hultman, T., Dormoy, V., Odero-Marah, V., Sabbisetti, V., Maguer-Satta, V., Rathmell, W.K., Engström, W., Decker, W. K., Bisson, W. H., Rojanasakul, Y., Luqmani, Y., Chen, Z. and Hu, Z. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis, 36. S254-S296. ISSN 0143-3334 doi: 10.1093/carcin/bgv039
  • Darbre, P. (2015) Endocrine disruption and human health. Elsevier (Academic Press), pp390. ISBN 9780128011393

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

This list was generated on Mon Aug 3 22:19:29 2015 BST.
Dr Philippa Darbre

Contact Details

Email:
p.d.darbre@reading.ac.uk
Telephone:
+44 (0) 118 378 7035
Fax:
0118 378 6642
Building:
205 Hopkins

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