- Professor Philippa Darbre
- Job Title:
- Programme Advisor for Biochemistry
- Areas of Interest:
Funding from the Breast Cancer Research Trust
Molecular and cellular mechanisms of action of oestrogen and oestrogen-mimicking chemicals in human breast cancer cells
- Studying cellular and molecular mechanisms by which human breast cancer cells escape from oestrogen regulation of cell proliferation as a model system for investigating the clinical problem of loss of response to endocrine therapy in breast cancer
- Focus on the effects of long-term low-dose environmental chemicals (alone and in combination) in human breast epithelial cells, especially in relation to how they may influence the hallmarks of cancer
- Laboratory currently has five postgraduate students, all self-funded from overseas
- Research groups / Centres:
Impact, Enterprise and Outreach:
- REF2014 Impact case study: The reduction in the use of potentially toxic chemicals in cosmetics, thus safeguarding human health
- Research on parabens has led to extensive media coverage and increasing public awareness of the issues surrounding useage of parabens in consumer products.
- Research on aluminium has led to extensive media coverage and increasing public awareness of issues surrounding use of aluminium-based salts as antiperspirants to control underarm perspiration.
- Media coverage on cosmetics and breast cancer has been international and includes websites, national/local newspaper and magazine articles, television interviews, documentaries and films.
- Application of the research on parabens and aluminium by industry has led to the availability of paraben-free and aluminium-free products on supermarket shelves.
- Research results have been adopted and used by non-government organisations (NGOs)
- Research results have been featured in numerous websites and in popular books.
- Scientific Advisor, European Commission-Committee on Health and Environmental Risks
- Scientific Advisory Board of the International Halifax Project
- Editorial board member for J. Applied Toxicology, Hormone Molecular Biology and Clinical Investigation
- Organizer and Plenary Speaker: Hormone Molecular Biology and Clinical Investigation.
- Member of Organising Committee of the International Meeting of the Journal of Steroid Hormone Biochemistry and Molecular Biology, held in Seefeld, Austria, September 2010
- External examiner MRes Medical Sciences, University of Newcastle
- Patron of the charity CancerActive
- Part 1: Biochemistry and Metabolism*
- Part 2: Life and Death of a Cell*
- Part 3: Cancer*, Medical Genetics, Medicinal Plants, Selected Topics in Endocrine Disease
(* Module coordinator)
- Prof F Mannello, University of Urbino, Italy
- Mr L Barr, Genesis Breast Cancer Prevention centre, University Hospital of South Manchester
- Prof C Exley, University of Keele
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