Staff Profile:Dr Michael Fry
- Dr Mike Fry
- Job Title:
- Associate Professor
Associate Professor in Biomedical Sciences
- Areas of Interest:
- Funding from British Heart Foundation
- Development of a mathematical model of platelet signalling and function - the Virtual Platelet - for in silico experimentation, drug discovery and diagnosis.
- Analysis of the non-genomic functions of histone deacetylases in cellular signalling using proteomic approaches - platelets as a model system.
- Analysis of phosphoinositide 3-kinases in cancer
- Evolution of cellular signalling systems
- Research groups / Centres:
Impact, Enterprise and Outreach:
- Joint Inventor on several patents linked to phosphoinositide 3-kinase research
- Host annual training day for British Biology Olympiad Finalists, Hosted BBO UK finals in 2013
- Local Ambassador for the Biochemical Society
- Part 1: The living Cell, The Living Cell 2, Laboratory and Study Skills for Biomedicine
- Part 2: Science Communication, Life and Death of a Cell, Molecular Biology of the Gene, Protein Structure and Function.
- Part 3: Cell Communication and Disease, Cancer
- Prof. Jon Gibbins, School of Biological Sciences
- Dr Chris Jones, School of Biological Sciences
- Dr Marcus Tindall, Department of Mathematics and Statistics
- Dr Fazil Baksh, Department of Mathematics and Statistics
- Dr Philippa Darbre, School of Biological Sciences
- Dr Bernard Payrastre, Inserm U1048, I2MC and Université Paul Sabatier, Toulouse, France
- Prof. Marco Falasca, Queen Mary University, London
- Dr Tania Maffuccci, Queen Mary University, London
YNumber of items: 7.
- Ray, S., Fry, M. J. and Darbre, P. D. (2011) Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells. Journal of Endocrinology, 208. pp. 21-29. ISSN 0022-0795 doi: 10.1677/JOE-10-0137
- Fry, M. J. (2009) Phosphoinositide (PI) 3-kinase assays. Methods in Molecular Biology, 462. pp. 345-362. ISSN 1064-3745 doi: 10.1007/978-1-60327-115-8
- Traer, C. J., Foster, F. M., Abraham, S. M. and Fry, M. J. (2006) Are class II phosphoinositide 3-kinases potential targets for anticancer therapies? Bull Cancer, 93 (5). E53-8. ISSN 1769-6917
- Pendaries, C., Tronchere, H., Arbibe, L., Mounier, J., Gozani, O., Cantley, L., Fry, M. J., Gaits-Iacovoni, F., Sansonetti, P. J. and Payrastre, B. (2006) PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. Embo Journal, 25 (5). pp. 1024-1034. ISSN 0261-4189 doi: 10.1038/sj.emboj.7601001
- Maffucci, T., Cooke, F. T., Foster, F. M., Traer, C. J., Fry, M. J. and Falasca, M. (2005) Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. Journal of Cell Biology, 169 (5). pp. 789-799. ISSN 0021-9525 doi: 10.1083/jcb.200408005
- Barry, F. A., Graham, G. J., Fry, M. J. and Gibbins, J. M. (2003) Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function? FEBS Letters, 553 (1-2). pp. 173-178. ISSN 0014-5793 doi: 10.1016/s0014-5793(03)01015-9
- Foster, F. M., Traer, C. J., Abraham, S. M. and Fry, M. J. (2003) The phosphoinositide (PI) 3-kinase family. Journal of Cell Science, 116 (15). pp. 3037-3040. ISSN 0021-9533 doi: 10.1242/jcs.00609
Fry MJ. Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? (2001) Breast Cancer Res. 3: 304-12.