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Dr Liam McGuffin – University of Reading

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Dr Liam McGuffin

Dr Liam McGuffin
Job Title:
Associate Professor
Liam McGuffin



Associate Professor in Bioinformatics

  • Admissions Tutor for BSc Biological Sciences with Industrial Experience
  • Director of Impact and Enterprise

Areas of Interest

  • Funding from MRC, Diamond Light Source, RCUK, International Governments 
  • Development of novel computational tools for the prediction of protein structures, functions and interactions from amino acid sequences. See: McGuffin Group Web servers
  • Prediction and experimental verification of the effects of mutations on protein folding and function
  • Application of computational methods for understanding the molecular mechanisms of cardiovascular function and disease
  • Development of algorithms for the evaluation of the quality of 3D models of proteins and setting data standards for theoretical model validation
  • High performance computing for the large scale structure and functional annotation of the proteomes of organisms relevant to food security
  • Participation in the biennial experiments for the Critical Assessment of Techniques for Protein Structure Prediction (CASP)

 Liam McGuffin citation

Member of the Molecular & Cellular Medicine Group

Impact, Enterprise and Outreach

  • STEM Ambassador working with local secondary schools
  • Science & Engineering Ambassador at Science Oxford for various events during National Science and Engineering Week and the Oxford Science Festival
  • Scientific consultancy, software development and data mining work for various biotech companies

Esteem Factors

  • RCUK Academic Fellowship (held from 2006-2011)
  • Invited speaker at the 8th, 9th and 10th Community Wide Experiments on the Critical Assessment of Techniques for Protein Structure Prediction
  • Member of the MRC College of Experts for Special Training Fellowships in Biomedical Informatics
  • Member of the program committee for the European Conference on Computational Biology


  • Part 1:
    • The Living Cell
    • Key Skills in Biological Sciences
    • Building Blocks of Life
  • Part 2:
    • Molecular Biology of the Gene: Expression, Function and Analysis
    • Molecular Genetics
    • Protein Structure and Function
    • Introduction to Bioinformatics and Computational Biology
    • Professional Careers Development
  • Part 3:
    • Projects in Bioinformatics and Systems Biology
  • MRes Biomedical Research
  • MSc in Molecular Medicine

International Collaborators

  • Professor Dr Filiz Gurel, Istanbul University, Turkey
  • Dr Luis V. Monteagudo, University of Zaragoza, Spain
  • Dr Valter Tucci, Istituto Italiano di Tecnologia, Genova, Italy
  • Dr Daniel Roche, The French National Sequencing Center (Genoscope), Évry, France
  • Dr Carsten Pedersen, University of Copenhagen, Denmark
  • Prof. Hans Thordal-Christensen University of Copenhagen, Denmark
  • Prof. Ralph Panstruga, Max-Planck Institute for Plant Breeding Research, Cologne, Germany
  • Dr Emiel Ver Loren van Themaat, Max-Planck Institute for Plant Breeding Research, Cologne, Germany
  • Prof. Gerd Pfeifer, City of Hope National Medical Center, California, USA
  • Dr Thomas Dunwell, City of Hope National Medical Center, California, USA
  • Dr Paulo Teixeira, University of Campinas, Brazil

National Collaborators

  • Dr Anne-Marie Mallon, MRC Harwell, Oxfordshire
  • Dr Pat Nolan, MRC Harwell, Oxfordshire
  • Dr Michelle Simon, MRC Harwell, Oxfordshire
  • Dr Rohannah Hussain, Diamond Light Source, Oxfordshire
  • Dr Laurence Bindschedler, Royal Holloway, University of London
  • Dr Tim Burgis, Imperial College London
  • Dr Pietro Spanu, Imperial College London
  • Dr Kevin Bryson, University College London
  • Dr Soren Sorensen, University College London
  • Prof David T. Jones, University College London
  • Prof Christine Oregno, University College London
  • Prof Mike Sternberg, Imperial College London
  • Prof Janet Thornton, European Bioinformatics Institute
  • Lorenz Wernisch, University College London
  • Dr Stefano Lise, University of Oxford
  • Dr Michael Sadowski, Synthace, London

Research groups / Centres


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Number of items: 66.


  • Zhou, N., Jiang, Y., Bergquist, T. R., Lee, A. J., Kacsoh, B. Z., Crocker, A. W., Lewis, K. A., Georghiou, G., Nguyen, H. N., Hamid, M. N., Davis, L., Dogan, T., Atalay, V., Rifaioglu, A. S., Dalkiran, A., Cetin-Atalay, R., Zhang, C., Hurto, R. L., Freddolino, P. L., Zhang, Y., Bhat, P., Supek, F., Fernández, J. M., Gemovic, B., Perovic, V. R., Davidović, R. S., Sumonja, N., Veljkovic, N., Asgari, E., Mofrad, M. R. K., Profiti, G., Savojardo, C., Martelli, P. L., Casadio, R., Boecker, F., Kahanda, I., Thurlby, N., McHardy, A. C., Renaux, A., Saidi, R., Gough, J., Freitas, A. A., Antczak, M., Fabris, F., Wass, M. N., Hou, J., Cheng, J., Hou, J., Wang, Z., Romero, A. E., Paccanaro, A., Yang, H., Goldberg, T., Zhao, C., Holm, L., Törönen, P., Medlar, A. J., Zosa, E., Borukhov, I., Novikov, I., Wilkins, A., Lichtarge, O., Chi, P.-H., Tseng, W.-C., Linial, M., Rose, P. W., Dessimoz, C., Vidulin, V., Dzeroski, S., Sillitoe, I., Das, S., Lees, J. G., Jones, D. T., Wan, C., Cozzetto, D., Fa, R., Torres, M., Vesztrocy, A. W., Rodriguez, J. M., Tress, M. L., Frasca, M., Notaro, M., Grossi, G., Petrini, A., Re, M., Valentini, G., Mesiti, M., Roche, D. B., Reeb, J., Ritchie, D. W., Aridhi, S., Alborzi, S. Z., Devignes, M.-D., Emily Koo, D. C., Bonneau, R., Gligorijević, V., Barot, M., Fang, H., Toppo, S., Lavezzo, E., Falda, M., Berselli, M., Tosatto, S. C. E., Carraro, M., Piovesan, D., Rehman, H. U., Mao, Q., Zhang, S., Vucetic, S., Black, G. S., Jo, D., Larsen, D. J., Omdahl, A. R., Sagers, L. W., Suh, E., Dayton, J. B., McGuffin, L., Brackenridge, D. A., Babbitt, P. C., Yunes, J. M., Fontana, P., Zhang, F., Zhu, S., You, R., Zhang, Z., Dai, S., Yao, S., Tian, W., Cao, R., Chandler, C., Amezola, M., Johnson, D., Chang, J.-M., Liao, W.-H., Liu, Y.-W., Pascarelli, S., Frank, Y., Hoehndorf, R., Kulmanov, M., Boudellioua, I., Politano, G., Di Carlo, S., Benso, A., Hakala, K., Ginter, F., Mehryary, F., Kaewphan, S., Björne, J., Moen, H., Tolvanen, M. E. E., Salakoski, T., Kihara, D., Jain, A., Šmuc, T., Altenhoff, A., Ben-Hur, A., Rost, B., Brenner, S. E., Orengo, C. A., Jeffery, C. J., Bosco, G., Hogan, D. A., Martin, M. J., O’Donovan, C., Mooney, S. D., Greene, C. S., Radivojac, P. and Friedberg, I. (2019) The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Genome Biology. ISSN 1474-760X (In Press)
  • Cheng, J., Choe, M.‐H., Elofsson, A., Han, K.‐S., Hou, J., Maghrabi, A. H. A., McGuffin, L. J., Menéndez‐Hurtado, D., Olechnovič, K., Schwede, T., Studer, G., Uziela, K., Venclovas, Č. and Wallner, B. (2019) Estimation of model accuracy in CASP13. Proteins: Structure, Function, and Bioinformatics. ISSN 0887-3585 doi:
  • El Sarraf, N., Gurel, F., Tufan, F. and McGuffin, L. J. (2019) Characterisation of HvVIP1 and expression profile analysis of stress response regulators in barley under Agrobacterium and Fusarium infections. PLoS ONE, 14 (6). ISSN 1932-6203 doi:
  • Adiyaman, R. and McGuffin, L. J. (2019) Methods for the refinement of protein structure 3D models. International Journal of Molecular Sciences, 20 (9). 2301. ISSN 1422-0067 doi:
  • McGuffin, L. J., Adiyaman, R., Maghrabi, A. H. A., Shuid, A. N., Brackenridge, D. A., Nealon, J. O. and Philomina, L. S. (2019) IntFOLD: an integrated web resource for high performance protein structure and function prediction. Nucleic Acids Research. gkz322. ISSN 1362-4962 doi:




















This list was generated on Wed Nov 20 15:51:49 2019 UTC.

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