Staff Profile:Dr Liam McGuffin

Dr Liam McGuffin
Job Title:
Associate Professor

Associate Professor in Bioinformatics

  • Admissions Tutor for BSc Biological Sciences with Industrial Experience
  • Director of Impact and Enterprise
Areas of Interest:
  • Funding from MRC, Diamond Light Source, RCUK, International Governments 
  • Development of novel computational tools for the prediction of protein structures, functions and interactions from amino acid sequences. See: Bioinformatics Web Servers
  • Prediction and experimental verification of the effects of mutations on protein folding and function
  • Application of computational methods for understanding the molecular mechanisms of cardiovascular function and disease
  • Development of algorithms for the evaluation of the quality of 3D models of proteins and setting data standards for theoretical model validation
  • High performance computing for the large scale structure and functional annotation of the proteomes of organisms relevant to food security
  • Participation in the biennial experiments for the Critical Assessment of Techniques for Protein Structure Prediction (CASP)

 Liam McGuffin citations

Member of the Molecular & Cellular Medicine Group

Research groups / Centres:

Impact, Enterprise and Outreach:

  • STEM Ambassador working with local secondary schools
  • Science & Engineering Ambassador at Science Oxford for various events during National Science and Engineering Week and the Oxford Science Festival
  • Scientific consultancy, software development and data mining work for various biotech companies

Esteem Factors:

  • RCUK Academic Fellowship (held from 2006-2011)
  • Invited speaker at the 8th, 9th and 10th Community Wide Experiments on the Critical Assessment of Techniques for Protein Structure Prediction
  • Member of the MRC College of Experts for Special Training Fellowships in Biomedical Informatics
  • Member of the program committee for the European Conference on Computational Biology


  • Part 1:
    • The Living Cell
    • Key Skills in Biological Sciences
    • Building Blocks of Life
  • Part 2:
    • Molecular Biology of the Gene: Expression, Function and Analysis
    • Molecular Genetics
    • Protein Structure and Function
    • Introduction to Bioinformatics and Computational Biology
    • Professional Careers Development
  • Part 3:
    • Projects in Bioinformatics and Systems Biology
  • MRes Biomedical Research
  • MSc in Molecular Medicine

International Collaborators:

  • Professor Dr Filiz Gurel, Istanbul University, Turkey
  • Dr Luis V. Monteagudo, University of Zaragoza, Spain
  • Dr Valter Tucci, Istituto Italiano di Tecnologia, Genova, Italy
  • Dr Daniel Roche, The French National Sequencing Center (Genoscope), Évry, France
  • Dr Carsten Pedersen, University of Copenhagen, Denmark
  • Prof. Hans Thordal-Christensen University of Copenhagen, Denmark
  • Prof. Ralph Panstruga, Max-Planck Institute for Plant Breeding Research, Cologne, Germany
  • Dr Emiel Ver Loren van Themaat, Max-Planck Institute for Plant Breeding Research, Cologne, Germany
  • Prof. Gerd Pfeifer, City of Hope National Medical Center, California, USA
  • Dr Thomas Dunwell, City of Hope National Medical Center, California, USA
  • Dr Paulo Teixeira, University of Campinas, Brazil

National Collaborators:

  • Dr Anne-Marie Mallon, MRC Harwell, Oxfordshire
  • Dr Pat Nolan, MRC Harwell, Oxfordshire
  • Dr Michelle Simon, MRC Harwell, Oxfordshire
  • Dr Rohannah Hussain, Diamond Light Source, Oxfordshire
  • Dr Laurence Bindschedler, Royal Holloway, University of London
  • Dr Tim Burgis, Imperial College London
  • Dr Pietro Spanu, Imperial College London
  • Dr Kevin Bryson, University College London
  • Dr Soren Sorensen, University College London
  • Prof David T. Jones, University College London
  • Prof Christine Oregno, University College London
  • Prof Mike Sternberg, Imperial College London
  • Prof Janet Thornton, European Bioinformatics Institute
  • Lorenz Wernisch, University College London
  • Dr Stefano Lise, University of Oxford
  • Dr Michael Sadowski, Synthace, London
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