Staff Profile:Professor Ian Jones

Name:

Professor Ian Jones

Job Title:

Academic, AMS Building

Responsibilities:

Areas of Interest:

The main interest in my group is how proteins, mostly viral proteins, carry out the functions for which they have evolved and how this activity contributes to the virus life cycle. A number of virus contribute the model systems we work on, retroviruses (HIV and MLV) hepaciviruses (hepatitis C virus) and baculoviruses (Autographa californica MNPV). Although these virus models are diverse, they share certain activities which are probably mechanistically related. For example, all are enveloped viruses and must fuse with the cell membrane in order to deliver their nucleic acid and formally begin an infectious cycle. The more we understand about what happens when a virus docks with, and then enters, a cell, the better our chance of preventing it, so although our studies are quite specialised, they contribute to the development of better anti viral therapies. We make extensive use of protein expression and mutagenesis in our studies which, when combined with functional assays, allow us to map the sequences involved in biological activity. Although largely a molecular group we have an increasing interest in the atomic structure of the proteins with which we work and we also work on the isolation of protein ligands through the use of peptide display libraries.

Ian Jones Group website

 

Research groups / Centres:

 Microbiology research group

Publications:

Y

Jump to: 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

Number of items: 52.

2013

• Porta, C., Xu, X., Loureiro, S., Paramasivam, S., Ren, J., Al-Khalil, T., Burman, A., Jackson , T., Blesham, G. J., Curry, S., Lomonossoff, G. P., Parida, S., Paton, D., Li, Y., Wilsden , G., Ferris, N., Owens, R., Kotecha, A., Fry , E., Stuart, D. I., Charleston, B. and Jones, I. M. (2013) Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity. Journal of Virological Methods, 187 (2). pp. 406-412. ISSN 0166-0934 doi: 10.1016/j.jviromet.2012.11.011
• Xu, X., Chen, Y., Zhao, Y., Liu, X., Dong, B., Jones, I. M. and Chen, H. (2013) Baculovirus superinfection: a probable restriction factor on the surface display of proteins for library screening. PLoS ONE, 8 (1). e54631. ISSN 1932-6203 doi: 10.1371/journal.pone.0054631
• Iourin, O., Harlos, K., El Omari, K., Lu, W., Kadlec, J., Iqbal, M., Meier, C., Palmer, A., Jones, I., Thomas, C., Brownlie, J., Grimes, J. M. and Stuart, D. I. (2013) Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (1). pp. 35-38. ISSN 1744-3091 doi: 10.1107/S1744309112049184
• Porta, C., Kotecha, A., Burman, A., Jackson, T., Ren, J., Loureiro, S., Jones, I. M., Fry, E. E., Stuart, D. I. and Charleston, B. (2013) Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen. PLoS Pathogens, 9 (3). e1003255. ISSN 1553-7374 doi: 10.1371/journal.ppat.1003255

2012

• O'Flynn, N. M. J., Patel, A., Kadlec, J. and Jones, I. M. (2012) Improving promiscuous mammalian cell entry by the baculovirus AcMNPV. Bioscience Reports. BSR20120093. ISSN 0144-8463 doi: 10.1042/BSR20120093
• Loureiro, S., Robinson, E., Chen, H., Phapugrangkul, P. , Colaco , C. and Jones, I. M. (2012) Vaccine glycoproteins tagged with the human Fc domain as second generation vaccine candidates. In: Baschieri, S. (ed.) Innovation in vaccinology. Springer, pp. 45-63. ISBN 9789400745421 doi: 10.1007/978-94-007-4543-8_3

2011

• Hijazi, K., Wang, Y., Scala, C., Jeffs, S., Longstaff, C., Stieh, D., Haggarty, B., Vanham, G., Schols, D., Balzarini, J., Jones, I., Hoxie, J., Shattock, R. and Kelly, C. G. (2011) DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4. PLoS ONE, 6 (12). e28307. ISSN 1932-6203 doi: 10.1371/journal.pone.0028307
• van Doremalen, N., Shelton, H., Roberts, K. L., Jones, I., Pickles, R. J., Thompso, C. I. and Barclay, W. S. (2011) A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets. PLoS ONE, 6 (10). e25755. ISSN 1932-6203 doi: 10.1371/journal.pone.0025755
• Seeds, R. E., Mukhopadhyay, S., Jones, I., Gordon, S. and Miller, J. L. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon. International immunopharmacology, 11 (7). pp. 794-801. ISSN 1878-1705 doi: 10.1016/j.intimp.2011.01.013
• Tuplin, A., Evans, D. J., Buckley, A., Jones, I. M., Gould, E. A. and Gritsun, T. S. (2011) Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus. Nucleic Acids Research, 39 (16). pp. 7034-7048. ISSN 1362-4962 doi: 10.1093/nar/gkr237
• Loureiro, S., Ren, J., Phapugrangkul, P., Colaco, C. A., Bailey, C. R., Shelton, H., Molesti, E., Temperton, N. J., Barclay, W. S. and Jones, I. (2011) Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines. Journal of virology, 85 (6). pp. 3010-3014. ISSN 1098-5514 doi: 10.1128/JVI.01241-10
• Shelton, H., Ayora-Talavera, G., Ren, J., Loureiro, S., Pickles, R. J., Barclay, W. S. and Jones, I. M. (2011) Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential. Journal of Virology, 85 (4). pp. 1875-1880. ISSN 0022-538X doi: 10.1128/JVI.01822-10

2010

• Kong, L., Sheppard, N. C., Stewart-Jones, G. B. E., Robson, C. L., Chen, H., Xu, X., Krashias, G., Bonomelli, C., Scanlan, C. N., Kwong, P. D., Jeffs, S. A., Jones, I. and Sattentau, Q. J. (2010) Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity. Journal of Molecular Biology, 403 (1). pp. 131-47. ISSN 0022-2836 doi: 10.1016/j.jmb.2010.08.033
• Papandréou, M.-J., Barbouche, R., Guieu, R., Rivera, S., Fantini, J., Khrestchatisky, M., Jones, I. and Fenouillet, E. (2010) Mapping of domains on HIV envelope protein mediating association with calnexin and protein-disulfide isomerase. The Journal of Biological Chemistry, 285 (18). pp. 13788-13796. ISSN 1083-351X doi: 10.1074/jbc.M109.066670

2009

• Koroleva, O., Calder, G., Pendle, A., Kim, S., Lewandowska, D., Simpson, C., Jones, I. M., Brown, J. and Shaw, P. (2009) Dynamic behavior of Arabidopsis eif4a-iii, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia. Plant Cell, 21 (5). 1592 -1606. ISSN 1040-4651 doi: DOI:10.1105/tpc.108.060434
• Tang, H. L., Qian, Y. Q., Ren, Y., Chen, H. Y., Jones, I. M., Yue, B., He, H. Y. and Tsang, S. C. (2009) Mesoporous concentric magnetic FePt core-shells nanoparticle with functionalized surfaces for capturing metal ions and DNA molecules. Journal of Nanoscience and Nanotechnology, 9 (8). pp. 4604-4610. ISSN 1533-4880 doi: 10.1166/jnn.2009.1212
• Ayora-Talavera, G., Shelton, H., Scull, M. A., Ren, J., Jones, I. M., Pickles, R. J. and Barclay, W. S. (2009) Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium. PLoS ONE, 4 (11). e7836. ISSN 1932-6203 doi: 10.1371/journal.pone.0007836

2008

• Oliver, T. H., Jones, I., Cook, J. M. and Leather, S. R. (2008) Avoidance responses of an aphidophagous ladybird, Adalia bipunctata, to aphid-tending ants. Ecological Entomology, 33 (4). pp. 523-528. ISSN 0307-6946 doi: 10.1111/j.1365-2311.2008.01009.x
• Law, M., Maruyama, T., Lewis, J., Giang, E., Tarr, A. W., Stamataki, Z., Gastaminza, P., Chisari, F. V., Jones, I. M., Fox, R. I., Ball, J. K., McKeating, J. A., Kneteman, N. M. and Burton, D. R. (2008) Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nature Medicine, 14 (1). pp. 25-27. ISSN 1078-8956 doi: 10.1038/nm1698
• Fenouillet, E., Lavillette, D., Loureiro, S., Krashias, G., Maurin, G., Cosset, F. L., Jones, I. M. and Barbouche, R. (2008) Contribution of redox status to hepatitis C virus E2 envelope protein function and antigenicity. The Journal of Biological Chemistry, 283 (39). pp. 26340-26348. ISSN 1083-351X doi: 10.1074/jbc.M805221200
• Harel, H. Y. M., Fontaine, V., Chen, H., Jones, I. M. and Millner, P. A. (2008) Display of a Maize cDNA library on baculovirus infected insect cells. Bmc Biotechnology, 8 (64). p. 6. ISSN 1472-6750 doi: 10.1186/1472-6750-8-64
• Mathewson, A. C., Bishop, A., Yao, Y., Kemp, F., Ren, J., Chen, H., Xu, X., Berkhout, B., van der Hoek, L. and Jones, I. M. (2008) Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2. Journal of General Virology, 89. pp. 2741-2745. ISSN 0022-1317 doi: 10.1099/vir.0.2008/003962-0
• Chen, H., Xu, X., Lin, H. H., Chen, S. H., Forsman, A., Aasa-Chapman, M. and Jones, I. M. (2008) Mapping the immune response to the outer domain of a human immunodeficiency virus-1 clade C gp120. Journal of General Virology, 89. pp. 2597-2604. ISSN 0022-1317 doi: 10.1099/vir.0.2008/003491-0
• Kadlec, J., Loureiro, S., Abrescia, N. G. A., Stuart, D. I. and Jones, I. M. (2008) The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines. Nature Structural & Molecular Biology, 15 (10). pp. 1024-1030. ISSN 1545-9985 doi: 10.1038/nsmb.1484

2007

• Fenouillet, E., Barbouche, R. and Jones, I. M. (2007) Cell entry by enveloped viruses: redox considerations for HIV and SARS-coronavirus. Antioxid Redox Signal, 9 (8). pp. 1009-1034. ISSN 1523-0864 doi: 10.1089/ars.2007.1639
• Chen, H. Y., Xu, X. D. and Jones, I. M. (2007) Immunogenicity of the outer domain of a HIV-1 clade C gp120. Retrovirology, 4 (33). p. 9. ISSN 1742-4690 doi: 10.1186/1742-4690-4-33
• Adamson, C. S., Yao, Y. X., Vasiljevic, S., Sy, M. S., Ren, J. and Jones, I. M. (2007) Novel single chain antibodies to the prion protein identified by phage display. Virology, 358 (1). pp. 166-177. ISSN 0042-6822 doi: 10.1016/j.virol.2006.08.023
• Barclay, W. S., Jones, I. M., Osborn, H. M. I., Phillipson, L., Ren, J. Y., Talevera, G. A. and Thompson, C. I. (2007) Probing the receptor interactions ofan H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands. Bioorganic & Medicinal Chemistry, 15 (12). pp. 4038-4047. ISSN 0968-0896 doi: 10.1016/j.bmc.2007.03.085

2006

• Aricescu, A. R., Assenberg, R., Bill, R. M., Busso, D., Chang, V. T., Davis, S. J., Dubrovsky, A., Gustafsson, L., Hedfalk, K., Heinemann, U., Jones, I. M., Ksiazek, D., Lang, C., Maskos, K., Messerschmidt, A., Macieira, S., Peleg, Y., Perrakis, A., Poterszman, A., Schneider, G., Sixma, T. K., Sussman, J. L., Sutton, G., Tarboureich, N., Zeev-Ben-Mordehai, T. and Jones, E. Y. (2006) Eukaryotic expression: developments for structural proteomics. Acta Crystallographica Section D-Biological Crystallography, 62. pp. 1114-1124. ISSN 0907-4449 doi: 10.1107/s0907444906029805
• Vasiljevic, S., Ren, J. Y., Yao, Y. X., Dalton, K., Adamson, C. S. and Jones, I. M. (2006) Green fluorescent protein as a reporter of prion protein folding. Virology Journal, 3. p. 9. ISSN 1743-422X doi: 10.1186/1743-422x-3-59
• Lavillette, D., Barbouche, R., Yao, Y. X., Boson, B., Cosset, F. L., Jones, I. M. and Fenouillet, E. (2006) Significant redox insensitivity of the functions of the SARS-CoV spike glycoprotein - Comparison with HIV envelope. The Journal of Biological Chemistry, 281 (14). pp. 9200-9204. ISSN 1083-351X doi: 10.1074/jbc.M512529200
• Pengelley, S. C., Chapman, D. C., Abbott, W. M., Lin, H. H., Huang, W., Dalton, K. and Jones, I. M. (2006) A suite of parallel vectors for baculovirus expression. Protein Expression and Purification, 48 (2). pp. 173-181. ISSN 1046-5928 doi: 10.1016/j.pep.2006.04.016

2005

• Galloway, C. S., Wang, P., Winstanley, D. and Jones, I. M. (2005) Comparison of the bacterial Enhancin-like proteins from Yersinia and Bacillus spp. with a baculovirus Enhancin. Journal of Invertebrate Pathology, 90 (2). pp. 134-137. ISSN 0022-2011 doi: 10.1016/j.jip.2005.06.008
• Barbouche, R., Lortat-Jacob, H., Jones, I. M. and Fenouillet, E. (2005) Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env. Molecular Pharmacology, 67 (4). pp. 1111-1118. ISSN 0026-895X doi: 10.1124/mol.104.008276
• Chen, H. Y., Xu, X. D., Bishop, A. and Jones, I. M. (2005) Reintroduction of the 2G12 epitope in an HIV-1 clade C gp120. Aids, 19 (8). pp. 833-835. ISSN 0269-9370
• Yong, F., Fox, D., Singh, S., Pengelley, S. and Jones, I. M. (2005) Use of GFP as a fusion marker in the baculovirus expression system. Febs Journal, 272. pp. 318-319. ISSN 1742-464X
• Pande, A., Carr, B. V., Wong, S. Y. C., Dalton, K., Jones, I. M., McCauley, J. W. and Charleston, B. (2005) The glycosylation pattern of baculovirus expressed envelope protein E2 affects its ability to prevent infection with bovine viral diarrhoea virus. Virus Research, 114 (1-2). pp. 54-62. ISSN 0168-1702 doi: 10.1016/j.virusres.2005.05.011
• Pengelley, S. C., Abbott, M. and Jones, I. M. (2005) A vector suite approach to baculovirus expression. Febs Journal, 272. p. 312. ISSN 1742-464X

2004

• Bowker, M., Bennett, R. A. and Jones, I. Z. (2004) CO Oxidation and the CO/NO Reaction on Pd(110) Studied Using "Fast" XPS and a Molecular Beam Reactor. Topics In Catalysis, 28 (1/4). pp. 25-30.
• Yao, Y. X., Ren, J. Y., Heinen, P., Zambon, M. and Jones, I. M. (2004) Cleavage and serum reactivity of the severe acute respiratory syndrome coronavirus spike protein. Journal of Infectious Diseases, 190 (1). pp. 91-98. ISSN 0022-1899 doi: 10.1086/421280
• Fenouillet, E., Barbouche, R. and Jones, I. M. (2004) HIV Env reduction postreceptor binding: a new target for AIDS treatment? Blood, 104 (1). p. 296. ISSN 0006-4971
• Jones, I. M. (2004) Hosting a killer. Chemistry World, 1 (8). pp. 28-31. ISSN 1473-7604
• Ojala, K., Koski, J., Ernst, W., Grabherr, R., Jones, I. and Oker-Blom, C. (2004) Improved display of synthetic IgG-binding domains on the baculovirus surface. Technology in Cancer Research & Treatment, 3 (1). pp. 77-84. ISSN 1533-0346
• Xu, X. D. and Jones, I. M. (2004) Rapid parallel expression in E-coli and insect cells: Analysis of five lef gene products of the Autographa californica multiple nuclear polyhedrosis virus (AcMNPV). Virus Genes, 29 (2). pp. 191-197. ISSN 0920-8569 doi: 10.1023/B:VIRU.0000036379.15968.4a
• Herrero-Martinez, E., Sabin, C. A., Lee, C. A., Jones, I. M., Pillay, D. and Emery, V. C. (2004) The effect of highly active antiretroviral therapy for HIV on the anti-HCV specific humoral immune response. Journal of Medical Virology, 72 (2). pp. 187-193. ISSN 0146-6615 doi: 10.1002/jmv.10578
• Adamson, C. S. and Jones, I. M. (2004) The molecular basis of HIV capsid assembly - five years of progress. Reviews in Medical Virology, 14 (2). pp. 107-121. ISSN 1052-9276 doi: 10.1002/rmv.418

2003

• Yao, Y. X., Ren, J. Y. and Jones, I. M. (2003) Amino terminal interaction in the prion protein identified using fusion to green fluorescent protein. Journal of Neurochemistry, 87 (5). pp. 1057-1065. ISSN 0022-3042 doi: 10.1046/j.1471-4159.2003.02039.x
• Adamson, C. S., Nermut, M. and Jones, I. M. (2003) Control of human immunodeficiency virus type-1 protease activity in insect cells expressing Gag-Pol rescues assembly of immature but not mature virus-like particles. Virology, 308 (1). pp. 157-165. ISSN 0042-6822 doi: 10.1016/s0042-6822(02)00141-1
• Zhao, Y., Chapman, D. A. and Jones, I. M. (2003) Improving baculovirus recombination. Nucleic Acids Research, 31 (2). E6-6. ISSN 1362-4962
• Barbouche, R., Miquelis, R., Jones, I. M. and Fenouillet, E. (2003) Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion. The Journal of Biological Chemistry, 278 (5). pp. 3131-3136. ISSN 1083-351X doi: 10.1074/jbc.M205467200
• Nermut, M. V., Zhang, W. H., Francis, G., Ciampor, F., Morikawa, Y. and Jones, I. M. (2003) Time course of gag protein assembly in HIV-1-infected cells: a study by immunoelectron microscopy. Virology, 305 (1). pp. 219-27. ISSN 0042-6822 doi: 10.1006/viro.2002.1692
• Adamson, C. S., Davies, A., Soneoka, Y., Nermut, M., Mitrophanous, K. and Jones, I. M. (2003) A block in virus-like particle maturation following assembly of murine leukaemia virus in insect cells. Virology, 314 (2). pp. 488-496. ISSN 0042-6822 doi: 10.1016/s0042-6822(03)00485-9

This list was generated on Wed May 22 20:33:58 2013 BST.

 

Pre 2003

Jones, I.M. (2002) Prions show their metal. Chemistry in Britain Vol 38, No.4, April 2002.

Chapple, S.D.J. and Jones, I.M. (2002) Non-polar distribution of green fluorescent protein on the surface of Autographa californica nucleopolyhedrovirus using a heterologous membrane anchor. Journal of Biotechnology 95, 269–275.

Deayton, J.R., Sabin, C.A., Britt W.B., Jones, I.M., Wilson P., Johnson, M.A. Griffiths, P.D., and Emery,V.C. (2002) Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy. AIDS. 8, 2129-2135.

Kakker, N.K., Mikhailov, M.V., Nermut, M.V. Jones, I.M. and Roy, P. (2002) Comparative analysis of the roles of simian immunodeficiency and bovine leukemia virus matrix proteins in Gag assembly in insect cells. Virology 299, 48-55

Lu, W., Chapple, S.D.J. Lissini O. and Jones I. M. (2002) Characterisation of a truncated soluble form of the baculovirus major envelope protein gp64. Protein Expression and Purification 24, 196-201.

Nermut, M.V., Zhang, W-H., Francis, G. Morikawa, Y. and Jones, I.M. (2002) Time course of Gag protein assemblyin HIV-1 infected cells: a study by immunoelectron microscopy. Virology 305, 219-27.