Staff Profile:Dr Amanda Callaghan

Name:

Dr Amanda Callaghan

Job Title:

Academic/Head of Admissions/Curator of the Cole Museum, Philip Lyle Building

Responsibilities:

Director of Undergraduate and Taught Postgraduate Admissions

Curator of the Cole Museum

Programme Advisor for the Zoology degree

Admissions Tutor for Zoology

Areas of Interest:

Evolution under environmental stress and the interaction between toxic environments, changes in the genome and phenotypic effects. Specific projects include: development of a Daphnia magna stress DNA microarray, mechanisms of gene amplification under toxic stress, insecticide resistance in pest insects, the role of membrane proteins in pesticide toxicity, short-term effects of exposure to organic and inorganic pollution in freshwater invertebrates and the development of biochemical and molecular biomarkers to detect exposure and effect.

Currently Funded Research Projects:

Daphnia Genomics Consortium 

Research groups / Centres:

Ecology research group

Centre for Wildlife Assessment and Conservation

Publications:

Y

Jump to: 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

Number of items: 28.

2010

• Pereira, J. L., Hill, C. J., Sibly, R. M., Bolshakov, V. N., Gonçalves, F., Heckmann, L.-H. and Callaghan, A. (2010) Gene transcription in Daphnia magna: effects of acute exposure to a carbamate insecticide and an acetanilide herbicide. Aquatic Toxicology , 97 (3). pp. 268-76. ISSN 0166-445X

2008

• Printes, L. B., Fellowes, M. D. E. and Callaghan, A. (2008) Clonal variation in acetylcholinesterase biomarkers and life history traits following OP exposure in Daphnia magna. Ecotoxicology and Environmental Safety, 71 (2). pp. 519-526. ISSN 0147-6513
• Shaw, J.R., Pfrender, M., Eads, B.D., Klaper, R., Callaghan, A., Colson, I., Jansen, B., Gilbert, D. and Colbourne, J.K. (2008) Daphnia as an emerging model for toxicological genomics. In: Hogstrand, C. and Kille, P. (eds.) Comparative Toxicogenomics. Elsevier Science, Oxford, UK, pp. 165-220. ISBN 9780444532749
• Hooper, H. L., Connon, R., Callaghan, A., Fryer, G., Yarwood-Buchanan, S., Biggs, J., Maund, S. J., Hutchinson, T. H. and Sibly, R. M. (2008) The ecological niche of Daphnia magna characterized using population growth rate. Ecology, 89 (4). pp. 1015-1022. ISSN 0012-9658
• Schriever, C.A., Callaghan, A., Biggs, J. and Liess, M. (2008) Freshwater biological indicators of pesticide contamination. Technical Report. Environment Agency pp85. ISBN 9781844328994
• Buss, D. S. and Callaghan, A. (2008) Interaction of pesticides with p-glycoprotein and other ABC proteins: A survey of the possible importance to insecticide, herbicide and fungicide resistance. Pesticide Biochemistry and Physiology, 90 (3). pp. 141-153. ISSN 0048-3575
• Connon, R., Hooper, H. L., Sibly, R. M., Lim, F. L., Heckmann, L. H., Moore, D. J., Watanabe, H., Soetaert, A., Cook, K., Maund, S. J., Hutchinson, T. H., Moggs, J., De Coen, W., Iguchi, T. and Callaghan, A. (2008) Linking molecular and population stress responses in Daphnia magna exposed to cadmium. Environmental Science & Technology, 42 (6). pp. 2181-2188. ISSN 0013-936X
• Heckmann, L. H., Sibly, R. M., Timmermans, M. and Callaghan, A. (2008) Outlining eicosanoid biosynthesis in the crustacean Daphnia. Frontiers in Zoology, 5. p. 9. ISSN 1742-9994
• Hayashi, Y., Heckmann, L. H., Callaghan, A. and Sibly, R. M. (2008) Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen. Ecotoxicology, 17 (4). pp. 246-251. ISSN 0963-9292
• Heckmann, L. H., Sibly, R. M., Connon, R., Hooper, H. L., Hutchinson, T. H., Maund, S. J., Hill, C. J., Bouetard, A. and Callaghan, A. (2008) Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna. Genome Biology, 9 (2). p. 14. ISSN 1474-760X

2007

• Heckmann, L. H., Callaghan, A., Hooper, H. L., Connon, R., Hutchinson, T. H., Maund, S. J. and Sibly, R. M. (2007) Chronic toxicity of ibuprofen to Daphnia magna: Effects on life history traits and population dynamics. Toxicology Letters, 172 (3). pp. 137-145. ISSN 0378-4274
• Swiergosz-Kowalewska, R., Bednarska, A. and Callaghan, A. (2007) Expression of metallothionein genes I and II in bank vole clethrionomys glareolus populations chronically exposed in situ to heavy metals. Environ Sci Technol, 41 (3). pp. 1032-7. ISSN 0013-936X
• Heckmann, L. H., Bouetard, A., Hill, C. J., Sibly, R. M. and Callaghan, A. (2007) A simple and rapid method for preserving RNA of aquatic invertebrates for ecotoxicogenomics. Ecotoxicology, 16 (6). pp. 445-447. ISSN 0963-9292

2006

• Heckmann, L. H., Connon, R., Hutchinson, T. H., Maund, S. J., Sibly, R. M. and Callaghan, A. (2006) Expression of target and reference genes in Daphnia magna exposed to ibuprofen. Bmc Genomics, 7. p. 8. ISSN 1471-2164
• Swiergosz-Kowalewska, R., Bednarska, A. and Callaghan, A. (2006) Metallothionein I and II gene expression as a response to metal contamination in bank vole Clethrionomys glareolus. Environmental Science and Technology, 41 (3). pp. 1032-7. ISSN 0013-936X
• Hooper, H. L., Connon, R., Callaghan, A., Maund, S. J., Liess, M., Duquesne, S., Hutchinson, T. H., Moggs, J. and Sibly, R. M. (2006) The use of image analysis to estimate population growth rate in Daphnia magna. Journal of Applied Ecology, 43 (4). pp. 828-834. ISSN 0021-8901

2005

• Gwynn, D. M., Callaghan, A., Gorham, J., Walters, K. F. A. and Fellowes, M. D. E. (2005) Resistance is costly: trade-offs between immunity, fecundity and survival in the pea aphid. Proceedings of the Royal Society B-Biological Sciences, 272 (1574). pp. 1803-1808. ISSN 0962-8452
• Dewhurst, R. E., Callaghan, A., Connon, R., Crane, M., Mather, J. D. and Wood, R. (2005) Toxicity testing of groundwater quality. Water and Environment Journal, 19 (1). pp. 17-24. ISSN 0951-7359

2004

• Printes, L. B. and Callaghan, A. (2004) A comparative study on the relationship between acetyl cholinesterase activity and acute toxicity in Daphnia magna exposed to anticholinesterase insecticides. Environmental Toxicology and Chemistry, 23 (5). pp. 1241-1247. ISSN 0730-7268
• Fellowes, M.D.E. and Callaghan, A. (2004) Garden entomology. In: The Royal Entomological Society's Introduction to Insect Science. Royal Entomological Society (London), p. 24.
• Andrews, M. C., Callaghan, A., Field, L. M., Williamson, M. S. and Moores, G. D. (2004) Identification of mutations conferring insecticide-insensitive AChE in the cotton-melon aphid, Aphis gossypii Glover. Insect Molecular Biology, 13 (5). pp. 555-561. ISSN 0962-1075
• Buss, D. S. and Callaghan, A. (2004) Molecular comparisons of the Culex pipiens (L.) complex esterase gene amplicons. Insect Biochemistry and Molecular Biology, 34 (5). pp. 433-441. ISSN 0965-1748

2003

• Connon, R., Dewhurst, R. E., Crane, M. and Callaghan, A. (2003) Haem peroxidase activity in Daphnia magna: A biomarker for sub-lethal toxicity assessments of kerosene-contaminated groundwater. Ecotoxicology, 12 (5). pp. 387-395. ISSN 0963-9292
• Maycock, D. S., Prenner, M. M., Kheir, R., Morris, S., Callaghan, A., Whitehouse, P., Morritt, D. and Crane, M. (2003) Incorporation of in situ and biomarker assays in higher-tier assessment of the aquatic toxicity of insecticides. Water Research, 37 (17). pp. 4180-4190. ISSN 0043-1354
• Fisher, T., Crane, M. and Callaghan, A. (2003) Induction of cytochrome P-450 activity in individual Chironomus riparius Meigen larvae exposed to xenobiotics. Ecotoxicology and Environmental Safety, 54 (1). pp. 1-6. ISSN 0147-6513
• Printes, L. B. and Callaghan, A. (2003) Intraclonal variability in Daphnia acetylcholinesterase activity: The implications for its applicability as a biomarker. Environmental Toxicology and Chemistry, 22 (9). pp. 2042-2047. ISSN 0730-7268
• Sheehan, P., Dewhurst, R. E., James, S., Callaghan, A., Connon, R. and Crane, M. (2003) Is there a relationship between soil and groundwater toxicity? Environmental Geochemistry and Health, 25 (1). pp. 9-16. ISSN 0269-4042
• Dewhurst, R. E., Wells, N. C., Crane, M., Callaghan, A., Connon, R. and Mather, J. D. (2003) Multivariate relationships between groundwater chemistry and toxicity in an urban aquifer. Environmental Toxicology and Chemistry, 22 (11). pp. 2813-2821. ISSN 0730-7268

This list was generated on Wed Feb 8 21:02:33 2012 GMT.

 

Pre 2003

Buss, D.S., McCaffery, A.R. and Callaghan, A. (2002) Evidence for P-glycoprotein modification of insect toxicity in mosquitoes of the Culex pipiens complex. Medical & Veterinary Entomology, 16, 218 - 223.

Callaghan, A. (2002). Spanish Fly Undone, Antenna, Bulletin of the Royal Entomological Society, 26 (3), 164-167.

Callaghan, A. and Denny, N. (2002). Evidence for an interaction between p-glycoprotein and cadmium toxicity in cadmium resistant and susceptible strains of Drosophila melanogaster. Ecotoxicology and Environmental Safety, 52, 211 – 213.

Callaghan, A., Fisher, T. Grosso, A., Holloway, G.J. and Crane, M. (2002) Effect of temperature and pirimiphos methyl on biochemical biomarkers in Chironomus riparius Meigen. Ecotoxicology and Environmental Safety, 52, 128-133.

Crane, M., Sildanchandra, W., Kheir, R. and Callaghan, A. (2002) Relationship between cholinesterase inhibition and developmental endpoints in Chironomus riparius Meigen exposed to an organophosphate pesticide. Ecotoxicology and Environmental Safety, 53,361 – 369.

Dewhurst, R. E., Wheeler, J.R., Chummun, K.S., Mather, J.D., Callaghan, A., and Crane, M. (2002) The comparison of rapid bioassays for the assessment of urban groundwater quality. Chemosphere, 47, 547-554.

Holloway, G.J., Callaghan, A. and Mpho, M. (2002). The effect of temperature and genotype on life history and fluctuating wing asymmetry in Culex pipiens mosquitoes. European Journal of Entomology, 99: 405-412.

Mpho, M., Holloway, G.J. and Callaghan, A.(2002). Wing asymmetry in Culex pipiens is not a heritable trait. Heredity, 88, 307-12.

Arnaud, L., Callaghan, A. and Haubruge, E. (2001). Insecticide resistance gene transmission by insecticide susceptible insects. Functional Ecology, 15, 812 - 813.

Callaghan, A. Hirthe, G., Fisher, T., and Crane, M. (2001) Effects of short-term exposure to chlorpyrifos on biochemical, behavioural and life-history biomarkers in Chironomus riparius Meigen. Ecotoxicology and Environmental Safety, 50, 19 - 24.

Dewhurst R.E, Mather J.D, Callaghan A, Connon R, Crane M. (2001). Assessing urban groundwater quality using biological and chemical methods. In: New Approaches to Characterising Groundwater Flow (K.P. Seiler and S. Wohnlich (eds.), Balkema Publishers, Munich, p 37-41.

Hirthe, G., Fisher, T. C., Crane, M. and Callaghan, A. (2001) Short-term exposure to lindane affects developmental parameters but has no effect on glutatione-s-transferase activity in Chironomus riparius larvae. Chemosphere, 44, 583-589.

Kheir R, Ibrahaim H, Lewis J, Callaghan A, and Crane M. (2001) Comparison of acetylcholinesterase and glutathione-s-transferase activities of Chironomus riparius Meigen exposed to chemical- spiked sediments. Bulletin of Environmental Contamination and Toxicology, 66, 603-610.

Mpho, M., Holloway, G.J. and Callaghan, A. (2001). A comparison of the effects of elevated temperature and insecticide exposure on fluctuating wing asymmetry and life history traits in Culex quinquefasciatus. Chemosphere, 45, 713 – 720.

Olsen, A., Fisher, T., Ellerbeck, L., Callaghan, A. and Crane, M. (2001) Variability in acetylcholinesterase and glutathione-s-transferase activities in Chironomus riparius Meigen deployed in situ at uncontaminated field sites. Environmental Toxicology and Chemistry, 20, 1725 – 1732.

Buss, D. and Callaghan, A. (2000) Involvement of p-glycoprotein in insecticide toxicity to Culex pipiens mosquitoes and implications for control programmes. BCPC Conference: PESTS & DISEASES 2000, 1-3, 441-446.

Crane, M., Higman, M., Olsen, T, Simpson, P., Callaghan, A. Fisher, T., and Kheir, R. (2000) An in situ system for exposing aquatic invertebrates to contaminated sediments. Environmental Toxicology and Chemistry, 19, 2715-2719.

Fisher, T.C., Crane, M. and Callaghan, A. (2000) A quality-controlled and optimised microtitreplate assay to detect acetylcholinesterase activity in individual Chironomus riparius meigen, for use as a biomarker of pesticide exposure.Environmental Toxicology and Chemistry. 19, 1749-1753.

Mpho, M., Holloway, G.J. and Callaghan, A.,(2000) The effect of larval density on life history and wing asymmetry in the mosquito Culex pipiens. Bulletin of Entomological Research, 90, 279-283.

Callaghan, A. and Holloway, G.J. (1999) Relationship between environmental stress and variance. Ecological Applications, 9, 456-462.

Thomas, C. J. and Callaghan, A. (1999) The use of garlic (Allium sativa) and lemon peel (Citrus limon) extracts as Culex pipiens larvacides: persistence and interaction with resistance mechanisms. Chemosphere, 39, 2489-2496.

Callaghan, A., Parker, P.J.N. and Holloway, G.J.(1998) The value of variance in esterase activity as a biomarker of long-term exposure to organophosphate insecticides in natural populations of Culex pipiens (L) (Diptera:Culicidae).Functional Ecology, 12, 436 - 441.

Callaghan, A., Makate, N., Guillemaud, T. and Raymond, M. (1998) Polymorphisms and fluctuations in gene copy number of amplified esterase genes in Culex pipiens mosquitoes. Insect Molecular Biology 7, 295 - 300.

Head, D.J., McCaffery, A.R. and Callaghan, A. (1998). Novel mutations in the III-IV linker of the para-homologous sodium channel gene associated with phenotypic nerve insensitivity in pyrethroid resistant Heliothis virescens and Helicoverpa armigera. Insect Molecular Biology, 7, 191-196.

Spencer, A., Price, N. and Callaghan, A. (1998) Mechanisms of malathion-specific resistance in a strain of the Rust Red Grain Beetle Cryptolestes ferrugineus (Stephens). Bulletin of Entomological Research, 88, 199-206.

Guillemaud, T., Makate, N., Raymond, M., Hirst, B., and Callaghan, A. (1997) Esterase gene amplification in OP resistant strains of Culex pipiens (Diptera:Culicidae).Insect Molecular Biology, 6, 319 - 327.

Holloway, G.J., Crocker, H. and Callaghan, A.(1997) The effects of novel and stressful environments on trait distribution. Functional Ecology, 11, 579-584.

McCaffery, A.R., Holloway, J., Head, D. J., West, A., Dubbledam, A.Tan, J., Subramaniam, V.R. and Callaghan, A. (1997) Nerve insensitivity resistance to pyrethroids in Heliothine Lepidoptera: Toxicology to Molecular Biology. Pesticide Science, 51, 315 - 320.

Parker, P.J.N. and Callaghan, A. (1997) The effect of low level organophosphate exposure on esterase activity and allele frequency in field populations of Simulium equinum (Diptera:Simulidae).Environmental Toxicology and Chemistry, 16, 2550 - 2555.

Laias, N. and Callaghan, A. (1996)Single ovarian development in Culex pipiens reared at high density.The Entomologist, 115, 17-19.

Raymond, M., Qiao, C.L. Callaghan, A., (1996) Esterase polymorphism in an insecticide susceptible population of the mosquito Culex pipiens .Genetical Research, 67, 19-26.

Callaghan, A. and Laias, N. (1995). Pulsed Field Gel Electrophoresis of mosquito DNA. Trends in Genetics, 11, 40-41.

Callaghan, A., Boirioux, V. Raymond, M. and Pasteur, N.(1994). Characterization and prevention of mobility changes in overproduced esterases from organophosphate resistant Culex pipiens complex mosquitoes, Medical and Veterinary Entomology, 8, 391-394.

Callaghan, A. (1993) Temperature-related activity loss andmobility changes of esterases associated with insecticideresistance in Culex pipiens mosquitoes, Medical and Veterinary Entomology, 7, 287 - 290.

Callaghan, A., Malcolm, C.A., and Hemingway, J. (1993). The selection and genetic analysis of esterase electromorphs in an Italian strain of Culex pipiens. Biochemical Genetics, 31, 459-473.

Callaghan, A., Malcolm, C.A. and Hemingway, J. (1991) Biochemical studies of A and B carboxylesterases from organophosphate resistant strains of an Italian Culex pipiens (Diptera:Culicidae). Pesticide Biochemistry and Physiology, 41, 198-206.

Callaghan, A. (1991) Mechanisms and detection of insecticide resistance: a review. Science Progress, 75, 423-438. (Invited paper).

Hemingway, J., Callaghan, A. and Kurtak, D.C. (1991). Biochemical studies on chlorphoxim resistance in adults and larvae of the Simulium damnosum complex. Bulletin of Entomological Research, 81, 401-406.

Raymond, M., Callaghan, A., Fort, P. and Pasteur, N. (1991). Worldwide migration of amplified insecticide resistance genes in mosquitoes. Nature, 350: 151-153

Callaghan, A., Poirie, M., and Raymond, M. (1990). Evolution of Insecticide Resistance. Trends in Ecology & Evolution, 5, 164.

Hemingway, J., Callaghan, A. and Amin, A. (1990). Mechanisms of organophosphate and carbamate resistance in Culex quinquefasciatus from Saudi Arabia. Medical and Veterinary Entomology, 4, 271-282.

Hemingway, J., Callaghan, A. and Kurtak, D.C. (1989). Temephos resistance in the Simulium damnosum complex (Theobald:Diptera:Simulidae): a comparative study of larvae and adults of forest and savannah strains of this species complex. Bulletin of Entomological Research, 79, 659-669.

Curtis, C.F., Lines, J.D., Ijumba, J., Callaghan, A. and Hill, N. (1987). The relative efficacy of repellents against mosquito vectors of disease. Medical and Veterinary Entomology 1, 109-119.

Curtis, C.F., Ijumba, J., Lines, J.D., Hill, N., and Callaghan, A. (1986). Mosquito repellent anklets and a theory of relativity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 841-842.

Other publications:

Callaghan, A. and Fellowes, M.D.E. (2008). Garden Entomology III. Booklet published by the Royal Entomological Society.

Paling, N. and Callaghan, A. (2007). Animal Diversity CD-ROM. Centre for Biosciences, Issue 20, 7-8.ISSN 1740-6692.

Fellowes, M.D.E. and Callaghan, A. (2004). Garden Entomology. The Royal Entomological Society's Introduction to Insect Science. 24 pp. Royal Entomological Society, London (in association with The Times).

 

 CETL Fellow in Applied Undergraduate Research Skills - CETL-AURS Project Evaluation

Fellow of the  Royal Entomological Society (past Vice-President)