Dr Sam Boateng
- +44 (0) 118 378 7041
- Lecturer in biomedical science
- Admissions Tutor for Biochemistry
Areas of Interest
- Funding from British Heart Foundation
- To study the process of cardiac cell adaptation, particularly in response to mechanical stress as a means to understanding the mechanisms associated with heart failure
- Metabolism in heart failure
- Remodelling of cardiac fibroblasts
- Role of circadian activity on myocardial growth and adaptation
- Institute for Cardiovascular & Metabolic Research
- Molecular & Cellular Medicine Group
Impact, Enterprise and Outreach
Recent involvement with "Mending broken hearts" British Heart Foundation campaign
Interviews with BBC television and radio
BBC Berkshire interview
Recent activities at the university of Reading
- Elected member of the British Society for Cardiovascular Research committee since 2011
- Professor Pieter de Tombe, Loyola University, Chicago
- Dr Jody Martin , Loyola University, Chicago
- Dr Robert Gaffin, University of Illinois at Chicago
- Dr Masahiko Hoshijima, UCSD, USA
- Dr Sassan Hafizi, University of Portsmouth
- Professor Ralph Knoell, Imperial College London
Research groups / Centres
- Pierrat, O. A., Paudyal, A., Woodruff, J., Koroleva, O. and Boateng, S. Y. (2017) The exon junction complex senses energetic stress and regulates contractility and cell architecture in cardiac myocytes. Bioscience Reports, 37 (4). BSR20170707. ISSN 0144-8463 doi: https://doi.org/10.1042/BSR20170707
- Paudyal, A., Dewan, S., Ikie, C., Whalley, B. J., de Tombe, P. P. and Boateng, S. Y. (2016) Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure. Journal of Physiology, 594 (12). pp. 3287-3305. ISSN 1469-7793 doi: https://doi.org/10.1113/JP271809
- Atkins, J. D., Boateng, S. Y., Sorensen, T. and McGuffin, L. J. (2015) Disorder prediction methods, their applicability to different protein targets and their usefulness for guiding experimental studies. International Journal of Molecular Sciences, 16 (8). pp. 19040-19054. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms160819040
- Ravishankar, D., Watson, K. A., Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2015.04.056
- Hooper, C. L., Paudyal, A., Dash, P. and Boateng, S. (2013) Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis. American Journal of Physiology - Heart and Circulatory Physiology, 304 (10). H1302-H1313. ISSN 1522-1539 doi: https://doi.org/10.1152/ajpheart.00004.2013
- Arif, I. S., Hooper, C. L., Greco, F., Williams, A. C. and Boateng, S. Y. (2013) Increasing doxorubicin activity against breast cancer cells using PPARγ-ligands and by exploiting circadian rhythms. British Journal of Pharmacology, 169 (5). pp. 1178-1188. ISSN 1476-5381 doi: https://doi.org/10.1111/bph.12202
- Hooper, C. L., Dash, P. R. and Boateng, S. Y. (2012) Lipoma preferred partner is a mechanosensitive protein regulated by nitric oxide in the heart. FEBS Open Bio, 2. pp. 135-144. ISSN 2211-5463 doi: https://doi.org/10.1016/j.fob.2012.05.005
- Boateng, S. Y., Senyo, S. E., Qi, L. X., Goldspink, P. H. and Russell, B. (2009) Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein. Journal of Molecular and Cellular Cardiology, 47 (4). pp. 426-435. ISSN 0022-2828 doi: https://doi.org/10.1016/j.yjmcc.2009.04.006
- Boateng, S. Y. and Goldspink, P. H. (2008) Assembly and maintenance of the sarcomere night and day. Cardiovasc Res, 77 (4). pp. 667-75. ISSN 0008-6363 doi: https://doi.org/10.1093/cvr/cvm048
- Boateng, S. Y., Senyo, S. E., Qi, L. X. and Russell, B. (2008) Nucleocytoplasmic shuttling of muscle LIM protein is required for myocyte remodelling and adaptation to hypertrophic stimuli. Journal of Molecular and Cellular Cardiology, 44 (4). p. 192. ISSN 0022-2828 doi: https://doi.org/10.1016/j.yjmcc.2008.02.193
SY, Berlin JB, Geenen DL, Margulies KB, de Tombe PP and Russell B. Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. Am J Physiol-Heart Circ Physiol 292(1):H259-69 (2007).
Lixin Qi and Boateng SY. The circadian protein Clock localizes to the sarcomeric Z-disk and is a sensor of myofilament cross-bridge activity in cardiac myocytes. Biochem Biophys Res Comm 352(4):1054-1059 (2006).
Lateef S, Boateng SY, Ahluwalia N, Hartman TJ, Hanley L and Russell B. Three-dimensional chemical structures by protein functionalised micron sized beads bound to polylysine coated silicone surfaces. J Biomed Mater Res A: 72A(4):373-80 (2005).
Boateng SY, Lateef S, Hartman TJ, Hanley L and Russell B. RGD and YIGSR synthetic peptides facilitate identical cellular adhesion as laminin and fibronectin but alter the physiology of neonatal cardiac myocytes. Am J Physiol Cell Physiol. (2005) Jan;288(1):C30-8. Epub 2004 Sep 15.
Boateng SY, Hartman TJ, Ahluwalia N, Vidula H, Desai TA and Russell B. Inhibition of fibroblast proliferation using silicone micropegs: Implications for cardiac tissue engineering and cell culturing. Am J Physiol-Cell Physiology 285:C171-C182 (2003).
Boateng S, Lateef SS, Crot CA, Motlagh D, Desai T, Samarel AM, Russell B and Hanley L. Peptides bound to silicone membranes and 3D micro fabrication for cardiac cell culture. Advanced Materials 14(6):461-463 (2002).
Lateef SS, Boateng S, Hartman TJ, Crot CA, Russell B and Hanley L. GRGDSP peptide bound silicone membranes withstand mechanical flexing in vitro and display enhanced fibroblast adhesion. Biomaterials 23:3159-3168 (2002).
Boateng SY, Naqvi R, Macleod K, Yacoub M and Boheler K. Short term low dose ramipril treatment normalises myocyte relaxation and calcium handling following cardiac hypertrophy in rats. Am J Physiol-Heart Circ Physiol 280(3):H1029-38 (2001).
Lateef S, Boateng S, Hartman T, Crot C, Russell B and Hanley L. Stretching and fibroblast growth on GRGDSP-peptide modified silicone membranes (Review). Polymeric materials: Science and Engineering 85:403-404 (2001).
Nikcevic G, Perhonen M, Boateng S and Russell B. Translation is regulated via the 3' untranslated region of α-myosin heavy chain mRNA by calcium, but not by its localization. J Muscle Res Cell Motil. 21(6):599-607 (2000).
Ribadeau-Dumas A, Brady M, Boateng SY, Schwartz K and Boheler KR. Sarco(Endo)plasmic reticulum Ca2+-ATPase (SERCA2) gene products are regulated post-transcriptionally during rat cardiac development. Cardiovas Res 43: 426-436 (1999).
Ationu A and Boateng S. The role of natriuretic peptides in cardiovascular disorders and human cardiac allografts (Review). Int J Mol Med 2: 235-239 (1998).
Boateng SY, Seymour A-M, Bhutta N, Dunn M, Yacoub M and Boheler K. Sub-antihypertensive doses of ramipril normalises calcium ATPase expression and function following cardiac hypertrophy in rats. J Mol Cell Cardiol. 30(12):2683-94 (1998).
Boateng S, Seymour A-M, Dunn M, Yacoub M and Boheler K. Inhibition of endogenous cardiac phosphatase activity and measurement of sarcoplasmic reticulum calcium uptake: a possible role of phospholamban phosphorylation in the hypertrophied myocardium. Biochem Biophys Res Comm 239: 701-705 (1997).
MU Koban, SY Boateng and K Boheler, The role of the sarcoplasmic reticulum calcium ATPase and its regulatory protein phospholamban in the developing myocardium. In: The Developing Heart (B.Ostadal: M. Nagano: N. Takeda: N.S Dhalla, eds) Lippincott-Ravens Publishers, New York, (1997).
Amarni M, Corbett J, Boateng SY, Dunn MJ and Yacoub MH. Kinetics of induction and protective effect of heat shock proteins following cardioplegic arrest. Ann-Thorac-Surg 61(5): 1407-11 (1996).
Amarni M, Corbett J, Allen NJ, O.Shea J, Boateng SY, May AJ, Dunn MJ and Yacoub MH. Induction of heat-shock proteins enhances myocardial and endothelial functional recovery after prolonged cardioplegic arrest. Ann-Thorac-Surg 57(1):157-160 (1994).