Dr Dyan Sellayah
119 Harborne Building
Areas of Interest
Dr. Sellayah's research aims to investigate the molecular mechanisms that govern fat (adipose) tissue development and function in the context of obesity. His specific focus is in:
- Investigating the developmental programming of brown adipose tissue thermogenesis.
- Assessing the Impact of maternal nutrition during development on offspring adipose tissue development and function.
- Elucidating the function of FTO in adipogenesis
- Establishing the therapeutic potential of metformin's effects on adipose tissue
- Evolutionary origins of obesity
Impact, Enterprise and Outreach
- Contributions to various Popular Science magazines, including Science News (US) and New Scientist.
- Radio interview for Voice of America on adipose tissue dysfunction in obesity
- Patent holder for weight loss therapy (U.S. Patent NO. 13/353, 174; Ref: SBMRI 10-029-02NP)
- Recipient of the MRC New Investigator Research Grant award (2017) of £409,989
- Junior Research Fellow, Linacre College, University of Oxford 2014-2015
- Paper selected in top 5 basic research articles of 2014 in the journal Endocrinology
- Research highlight, Nature Medicine:17:1356, 2011
Part 3: Medical Genetics
- Prof Roger Cox (MRC Harwell)
- Dr Felino Cagampang (University of Southampton)
- Prof Dame Frances Ashcroft (University of Oxford)
Research groups / Centres
- Sellayah, D. (2018) The impact of early human migration on brown adipose tissue evolution and its relevance to the modern obesity pandemic. Journal of the Endocrine Society. ISSN 2472-1972 doi: https://doi.org/10.1210/js.2018-00363 (In Press)
- Sellayah, D. and Cagampang, F. R. (2018) The divergent effect of maternal protein restriction during pregnancy and postweaning high-fat diet feeding on blood pressure and adiposity in adult mouse offspring. Nutrients, 10 (12). 1832. ISSN 2072-6643 doi: https://doi.org/10.3390/nu10121832
- Merkestein, M. and Sellayah, D. (2015) Role of FTO in adipocyte development and function: recent insights. International Journal of Endocrinology, 2015. 521381. ISSN 1687-8337 doi: https://doi.org/10.1155/2015/521381
- Merkestein, M., Laber, S., McMurray, F., Andrew, D., Gregor, S., Sanderson, J., Li, M., Usher, S., Sellayah, D., Ashcroft, F. M. and Cox, R. D. (2015) FTO influences adipogenesis by regulating mitotic clonal expansion. Nature Communications, 6. 6792. ISSN 2041-1723 doi: https://doi.org/10.1038/ncomms7792
- Sellayah, D., Dib, L., Anthony, F. W., Watkins, A. J., Flemming, T. P., Hanson, M. A. and Cagampang, F. R. (2014) Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding of diet-induced thermogenesis in adult mouse offspring. European Journal of Nutrition, 53 (7). pp. 1523-1531. ISSN 1436-6215 doi: https://doi.org/10.1007/s00394-014-0657-4
- Merkestein, M., Cagampang, F. R. and Sellayah, D. (2014) Fetal programming of adipose tissue function: an evolutionary perspective. Mammalian Genome, 25 (9-10). pp. 413-423. ISSN 1432-1777 doi: https://doi.org/10.1007/s00335-014-9528-9
- Sellayah, D., Cagampang, F. R. and Cox, R. D. (2014) On the evolutionary origins of obesity: a new hypothesis. Endocrinology, 155 (5). pp. 1573-1588. ISSN 1945-7170 doi: https://doi.org/10.1210/en.2013-2103
- Sellayah, D. and Sikder, D. (2014) Orexin restores aging-related brown adipose tissue dysfunction in male mice. Endocrinology, 155 (2). pp. 485-501. ISSN 1945-7170 doi: https://doi.org/10.1210/en.2013-1629
Sellayah D, Sikder D. Feeding the heat on brown fat. Annals of the New York Academy of Sciences 2013: 1302(1):11-23.
Sellayah D, Sikder D. Food for thought: Understanding the multifaceted nature of orexins. Endocrinology 2013: 154(11):3990-9.
Sellayah D, Sikder D. Orexin receptor-1 mediates brown fat developmental differentiation. Adipocyte 2012: 1:58-63.
Sellayah D, Bharaj P, Sikder D. Orexin is required for brown adipose tissue development, differentiation and function. Cell Metabolism 2011: 14:478-490.
Sellayah D, Sek K, Anthony FW, Hanson MA, Cagampang FR. Sensitivity of housekeeping genes in the hypothalamus to mismatch in diets between pre- and postnatal periods in mice. Neuroscience Letters 2008: 447(1):54-57.
Sellayah D, Sek K, Anthony FW, Watkins AJ, Osmond C, Fleming TP, Hanson MA, Cagampang FR. Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods. Brain Research 2008: 1237:146-152.