Dr Andrew Bicknell
Responsibilities
- School Director of Teaching and Learning
- Admissions tutor for BSc Biomedical Sciences
Areas of Interest
- Role of POMC derived and tachykinins peptides in the regulation of adrenal, adipocyte and platelet function.
- Purification of peptide and protein hormones.
- Development and purification of antibodies.
Member of the Molecular & Cellular Medicine Group
Impact, Enterprise and Outreach
- Supplied antibodies and POMC peptides to various labs around the world.
- Purified snake venom proteins that are potential therapeutic targets.
- Various outreach activities for A-level students.
Teaching
- Part 1: Genes and Chromosomes, Pathology: Introduction to Human Disease
- Part 2: Immunology, Endocrinology, Recombinant DNA exercise
- Part 3: Selected topics in Endocrinology and Endocrine Disease, Mammalian Reproduction, Therapeutics 3
- Masters: MRes in Biomedical Research.
International Collaborators
- Dr. Hugh Bennett, Montreal, Canada.
- Dr Patrick McDonough, Vala Biosciences, San Diego, USA.
National Collaborators
- Dr Peter King, William Harvey Research Institute, London
- Dr Dominic Cavlan, William Harvey Research Institute, London.
Research groups / Centres
Publications
Y
Number of items: 22.
2020
- Layfield, H. J., Williams, H. F., Ravishankar, D., Mehmi, A., Sonavane, M., Salim, A., Vaiyapuri, R., Lakshminarayanan, K., Vallance, T. M., Bicknell, A. B., Trim, S. A., Patel, K. and Vaiyapuri, S. (2020) Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox. Toxins, 12 (5). 309. ISSN 2072-6651 doi: https://doi.org/10.3390/toxins12050309
2019
- Laird, M., Glister, C., Cheewasopit, W., Satchell, L. S., Bicknell, A. B. and Knight, P. G. (2019) ‘Free’ inhibin α subunit is expressed by bovine ovarian theca cells and its knockdown suppresses androgen production. Scientific Reports, 9. 19793. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-019-55829-w
- Williams, H., Mellows, B., Mitchell, R., Sfyri, P., Layfield, H., Salamah, M., Vaiyapuri, R., Collins-Hooper, H., Bicknell, A., Matsakas, A., Patel, K. and Vaiyapuri, S. (2019) Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases, 13 (1). e0007041. ISSN 1935-2735 doi: https://doi.org/10.1371/journal.pntd.0007041
- Williams, H. F., Layfield, H. J., Vallance, T., Patel, K., Bicknell, A. B., Trim, S. A. and Vaiyapuri, S. (2019) The urgent need to develop novel strategies for the diagnosis and treatment of snakebites. Toxins, 11 (6). 363. ISSN 2072-6651 doi: https://doi.org/10.3390/toxins11060363
2018
- Holbrook, L., Sandhar, G. K., Sasikumar, P., Schenk, M. P., Stainer, A. R., Sahli, K., Flora, G. D., Bicknell, A. B. and Gibbins, J. M. (2018) A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis. Journal of Thrombosis and Haemostasis, 16 (2). pp. 367-377. ISSN 1538-7836 doi: https://doi.org/10.1111/jth.13878
- Williams, H. F., Hayter, P., Ravishankar, D., Baines, A., Layfield, H. J., Croucher, L., Wark, C., Bicknell, A. B., Trim, S. and Vaiyapuri, S. (2018) Impact of Naja nigricollis venom on the production of methaemoglobin. Toxins, 10 (12). 539. ISSN 2072-6651 doi: https://doi.org/10.3390/toxins10120539
2017
- Williams, H. F., Vaiyapuri, R., Gajjeraman, P., Hutchinson, G., Gibbins, J. M., Bicknell, A. B. and Vaiyapuri, S. (2017) Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: the views of clinicians. Toxicon, 130. pp. 44-46. ISSN 0041-0101 doi: https://doi.org/10.1016/j.toxicon.2017.02.025
2013
- Satchell, L., Glister, C., Bleach, E. C., Glencross, R., Bicknell, A., Dai, Y., Anand-Ivell, R., Ivell, R. and Knight, P. G. (2013) Ovarian expression of insulin-like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles. Endocrinology, 154 (5). 1897-1906. ISSN 1945-7170 doi: https://doi.org/10.1210/en.2012-2232
2012
- Glister, C., Satchell, L., Michael, A. E., Bicknell, A. B. and Knight, P. G. (2012) The anti-epileptic drug Valproic Acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro. PLoS ONE, 7 (11). e49553. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0049553
- Vaiyapuri, S., Hutchinson, E. G., Ali, M. S., Dannoura, A., Stanley, R. G., Harrison, R. A., Bicknell, A. B. and Gibbins, J. M. (2012) Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions. The Journal of Biological Chemistry, 287 (31). pp. 26235-26244. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M112.381483
- Holbrook, L.-M., Sasikumar, P., Stanley, R. G., Simmonds, A. D., Bicknell, A. B. and Gibbins, J. M. (2012) The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function. Journal of Thrombosis and Haemostasis, 10 (2). pp. 278-288. ISSN 1538-7933 doi: https://doi.org/10.1111/j.1538-7836.2011.04593.x
2010
- Vaiyapuri, S., Harrison, R. A., Bicknell, A., Gibbins, J. M. and Hutchinson, E. G. (2010) Purification and functional characterisation of Rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. PLoS ONE, 5 (3). e9687. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0009687
2009
- Bicknell, K. A., Harmer, S. C., Yiangson, S., Lockwood, W. and Bicknell, A. B. (2009) Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity? Molecular and Cellular Endocrinology , 300 (1-2). pp. 71-76. ISSN 0303-7207 doi: https://doi.org/10.1016/j.mce.2008.09.032
- Pepper, D. J. and Bicknell, A. B. (2009) The stimulation of mitogenic signaling pathways by N-POMC peptides. Molecular and Cellular Endocrinology, 300 (1-2). pp. 77-82. ISSN 0303-7207 doi: https://doi.org/10.1016/j.mce.2008.09.021
2008
- Harmer, S. C., Pepper, D. J., Cooke, K., Bennett, H. P. J. and Bicknell, A. B. (2008) Evidence of a possible role for Lys-gamma 3-MSH in the regulation of adipocyte function. Journal of Endocrinology, 196 (1). pp. 149-158. ISSN 0022-0795 doi: https://doi.org/10.1677/JOE-07-0391
- Bicknell, A. B. (2008) The tissue-specific processing of pro-opiomelanocortin. Journal of Neuroendocrinology, 20 (6). pp. 692-699. ISSN 0953-8194 doi: https://doi.org/10.1111/j.1365-2826.2008.01709.x
2007
- Lichtenauer, U. D., Duchniewicz, M., Kolanczyk, M., Hoeflich, A., Hahner, S., Else, T., Bicknell, A. B., Zemojtel, T., Stallings, N. R., Schulte, D. M., Kamps, M. P., Hammer, G. D., Scheele, J. S. and Beuschlein, F. (2007) Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis. Endocrinology, 148 (2). pp. 693-704. ISSN 0013-7227 doi: https://doi.org/10.1210/en.2006-0681
- Bicknell, A.B. (2007) Pro-opiomelanocortin (POMC). In: Fink, G. (ed.) Encyclopedia of Stress. Academic Press, Oxford, pp. 233-240. ISBN 9780120885039
2005
- Harmer, S. C. and Bicknell, A. B. (2005) Role of gamma-MSH peptides in the regulation of adrenal steroidogenesis. Peptides, 26 (10). pp. 1944-1951. ISSN 0196-9781 doi: https://doi.org/10.1016/j.peptides.2004.11.028
2004
- Hansen, I. A., Fassnacht, M., Hahner, S., Hammer, F., Schammann, M., Meyer, S. R., Bicknell, A. B. and Allolio, B. (2004) The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease. Endocrinology, 145 (4). pp. 1898-1905. ISSN 0013-7227 doi: https://doi.org/10.1210/en.2003-0930
- Harmer, S. C. and Bicknell, A. B. (2004) The role of the melanocortin 3 receptor in mediating the effects of gamma-MSH peptides on the adrenal. Endocrine Research, 30 (4). pp. 629-635. ISSN 0743-5800 doi: https://doi.org/10.1081/erc-200043906
2003
- Bicknell, A. B. (2003) Identification of a serine protease involved with the regulation of adrenal growth. In: Cone, R. D. (ed.) Melanocortin System. Annals of the New York Academy of Sciences, 994. New York Acad Sciences, New York, pp. 118-122. ISBN 0077-8923 1573314420
Pre 2003
Bicknell AB (2002) Identification of a receptor for N-POMC peptides Endo Res 28 309-314.
Bicknell AB and Lowry PJ (2002) Adrenal growth is controlled by expression of specific proopiomelanocortin serine protease in the outer adrenal cortex. Endo Res 28 589-595.
Omer S, Lomthaisong K and Bicknell AB (2002) Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues Endo Res 28 339-348.
Neville SE, Baigent SM, Bicknell AB, Lowry PJ and Gladwell RT (2002) Hox gene expression in adult tissues with particular reference to the adrenal gland. Endo Res 28 669-673.
Bicknell AB (2002) Identification of the protease that cleaves pro-gamma-MSH: the dawning of a new era in adrenal physiology. J Endocrinology 172 405-410.
Bicknell AB, Lomthaisong K, Woods RJ, Hutchinson EG, Bennett HPJ, Gladwell RT, and Lowry PJ (2001) Characterization of a serine protease that cleaves pro-g-melanotropin at the adrenal to stimulate growth. Cell 105 903-912
Bicknell AB, Lomthaisong K, Gladwell RT, and Lowry PJ (2000) Agouti related protein expression in the adrenal cortex. implications for novel autocrine mechanisms modulating the actions of pro-opiomelanocortin peptides. J Neuroend 12 977-982.
Bicknell AB and Lowry PJ (2000) Pro-opiomelanocortin (POMC). In: Fink, G ed. Encyclopedia of Stress San Diego:Academic Press pp 257-265.
Bicknell AB, Savva D and Lowry PJ (1996) POMC and adrenal function. Endo Res 22 385-393.